| Fas-activated serine-threonine kinase | <enzyme> Phosphorylates tia-1 during fas-mediated apoptosis; contains proline-rich sh3-binding domains; mw 60-63 kD; genbank x86779 Registry number: EC 2.7.10.- Synonym: fast kinase (26 Jun 1999) |
|---|---|
| killer cells, lymphokine-activated | Cytolytic lymphocytes with the unique capacity of killing natural killer (nk)-resistant fresh tumour cells. They are interleukin-2-activated nk cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. Lak cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |
| fluorescence-activated cell sorter | <technique> Flow cytometry is an emerging technique which holds great promise for the separation, classification and quantitation of blood cells and antibodies which affect blood cells. Complex computerised instruments are used to pass a monocellular stream of cells, platelets or other microscopic particulate elements through a beam of laser light. The cells are categorised first by size and then computer analysed to sort the mixture of cellular elements into cell type by size. Cells are labelled with fluorescent dye and then passed, in suspending medium, through a narrow dropping nozzle so that each cell is in a small droplet. A laser based detector system is used to excite fluorescence and droplets with positively fluorescent cells are given an electric charge. Charged and uncharged droplets are separated as they fall between charged plates and so collect in different tubes. The machine can be used either as an analytical tool, counting the number of labelled cells in a population or to separate the cells for subsequent growth of the selected population. Further sophistication can be built into the system by using a second laser system at right angles to the first to look at a second fluorescent label or to gauge cell size on the basis of light scatter. The great strength of the system is that it looks at large numbers of individual cells and makes possible the separation of populations with, for example: particular surface properties. Tabulation of counted data in conjunction with size analysis enables determination of relative percentages of each specific cellular subset for which monoclonal antibody conjugates are utilised, even when the size of the cell is identical to other subset species. Flow cytometry is a slightly imprecise but common term for the use of the Fluorescence-activated Cell Sorter (FACS). (01 Dec 1998) |
| fluorescence-activated cell sorting | <technique> A technique for separating and sorting cells marked with a fluorescent label based on how much they fluoresce at a particular wavelength. (12 Jan 1998) |
| light-activated resin | A resin which uses visible or ultraviolet light to excite a photoinitiator which interacts with an amine to form free radicals and initiate polymerization. Used mainly in restorative dentistry. Synonym: light-activated resin. (05 Mar 2000) |
| anosognosic epilepsy | Epilepsy characterised by attacks of which the person is unaware. Synonym: anosognosic seizures. (05 Mar 2000) |
| automatic epilepsy | <neurology> Seizures with elaborate and multiple sensory, motor, and/or psychic components. A common feature is the clouding of consciousness and amnesia for the event. Some clinical manifestations may include more complex behaviours like burst of anger, emotional outbursts, fear or automatisms. The EEG often reveals spike discharges in the temporal lobe during sleep. (02 Jan 1998) |
| autonomic epilepsy | Episodes of autonomic dysfunction presumably due to diencephalic irritation. Synonym: diencephalic epilepsy, vasomotor epilepsy, vasovagal epilepsy. (05 Mar 2000) |
| benign childhood epilepsy with centrotemporal spikes | A specific epilepsy syndrome beginning in childhood and remitting in adolescence, characterised by nocturnal simple partial motor seizures or generalised tonic-clonic seizures. EEG shows centrotemporal spikes that are activated by sleep and an otherwise normal EEG background. (05 Mar 2000) |
| major epilepsy | tonic-clonic seizure |
| vasomotor epilepsy | Episodes of autonomic dysfunction presumably due to diencephalic irritation. Synonym: diencephalic epilepsy, vasomotor epilepsy, vasovagal epilepsy. (05 Mar 2000) |
| vasovagal epilepsy | Episodes of autonomic dysfunction presumably due to diencephalic irritation. Synonym: diencephalic epilepsy, vasomotor epilepsy, vasovagal epilepsy. (05 Mar 2000) |
| generalised epilepsy | A major category of epilepsy syndromes characterised by one or more types of generalised seizures. (05 Mar 2000) |
| generalised tonic-clonic epilepsy | tonic-clonic seizure |
| masked epilepsy | A form of epilepsy characterised by a paroxysmal disturbance, such as headache or vomiting, associated with an epileptic electroencephalographic pattern. (05 Mar 2000) |