| vaccine lymph | Vaccinia lymph, that collected from the vesicles of vaccinia infection, and used for active immunization against smallpox. (05 Mar 2000) |
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| vaccine, flu | The flu (influenza) vaccine is recommended for persons at high risk for serious complications from influenza infection, including everyone 65 or over; people with chronic diseases of the heart, lung or kidneys, diabetes, immunosuppression, or severe forms of anaemia; residents of nursing homes and other chronic-care facilities, children and teenagers taking aspirin therapy (and who may therefore be at risk for developing reye syndrome after an influenza infection), and those in close or frequent contact with anyone at high risk. Persons with an allergy to eggs should not receive influenza vaccine. (12 Dec 1998) |
| vaccine, influenza | See Vaccine, flu. Vaccination, dtap: like dpt, dtap protects from diphtheria, pertussis (whooping cough) and tetanus. Dtap is the same as dtp, except that it contains only acellular pertussis vaccine which is thought to cause fewer of the minor reactions associated with immunization and is also probably less likely to cause the more severe reactions occasionally seen following pertussis vaccination. Dtap is currently recommended only for the shots given at 18 months and 4-6 years of age. Vaccination, dt: dt (diphtheria and tetanus) vaccine does not protect from pertussis and is usually reserved for individuals who have had a significant adverse reaction to a dpt shot or who have a personal or family history of a seizure disorder or brain disease. (12 Dec 1998) |
| vaccineation, serum hepatitis | See Vaccination, hepatitis b. (12 Dec 1998) |
| vaccines | Vaccines are microbial preparations of killed or modified microorganisms which can stimulate an immune response in the body in order to prevent future infection with similar microorganism. The smallpox vaccine has totally eliminated the smallpox disease from our planet. (12 Dec 1998) |
| vaccines, attenuated | Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity. (12 Dec 1998) |
| vaccines, combined | Two or more vaccines in a single dosage form. (12 Dec 1998) |
| vaccines, conjugate | Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognised by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection. (12 Dec 1998) |
| vaccines, DNA | Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers. (12 Dec 1998) |
| vaccines, inactivated | Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins. (12 Dec 1998) |
| vaccines, synthetic | Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified. (12 Dec 1998) |
| vaccinia | <dermatology> The cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. (18 Nov 1997) |
| vaccinia gangrenosa | A severe or even fatal form of vaccinia occurring chiefly in subjects with an immunologic deficiency or dyscrasia and characterised by progressive enlargement of the initial and also of secondary lesions. Synonym: vaccinia gangrenosa. (05 Mar 2000) |
| vaccinia virus | <molecular biology, virology> DNA viruses used in several biotechnology applications, including expression vector systems. Because they can hold quite a lot of DNA, they can be used to make more than one protein at once in a cell, which can be useful for making proteins with more than one polypeptide chain. (14 Nov 1997) |
| vaccinial | Relating to vaccinia. (05 Mar 2000) |