| AD | accident dispensary; acetate dialysis; active disease; acute dermatomyositis; addict, addiction; ade... |
|---|---|
| ADPKD | autosomal dominant polycystic kidney disease |
| ADVIRC | autosomal dominant vitreo-retinochoroidopathy |
| CPXD | chondrodysplasia punctata, X-linked dominant |
| DEBS | dominant epidermolysis bullosa simplex |
| threshold trait | A trait that falls into natural groups that originate not in categorically distinct causes but in whether or not the outcome attains critical values; e.g., gallstones may result from a categorical cause or from unusual levels of causal factors that themselves show no evidence of grouping. Synonym: liminal trait. (05 Mar 2000) |
|---|---|
| trait | A qualitative characteristic; a discrete attribute as contrasted with metrical character. A trait is amenable to segregation rather than quantitative analysis; it is an attribute of phenotype, not of genotype. Origin: Fr. From L. Tractus, a drawing out, extension (05 Mar 2000) |
| liminal trait | A trait that falls into natural groups that originate not in categorically distinct causes but in whether or not the outcome attains critical values; e.g., gallstones may result from a categorical cause or from unusual levels of causal factors that themselves show no evidence of grouping. Synonym: liminal trait. (05 Mar 2000) |
| balanced lethal system | <genetics> A population with non-linked, recessive alleles of a gene, where an individual who has two copies of the recessive allele and is therefore homozygous is dead, while an individual who has only one copy of it, and one copy of a different allele (and is heterozygous) survives. (09 Oct 1997) |
| genes, lethal | Genes which result in the premature death of the organism; dominant lethal genes kill heterozygotes, whereas recessive lethal genes kill only homozygotes. (12 Dec 1998) |
| genetic lethal | A disorder that prevents effective reproduction by those affected; e.g., Klinefelter syndrome. (05 Mar 2000) |
| granuloma, lethal midline | A non-neoplastic disease of unknown aetiology beginning with inflammation, ulceration, and perforation of nose and palate and progressing to gradual destruction of midline facial structures. (12 Dec 1998) |
| chicken embryo lethal orphan virus | <virology> A virus with characteristics of adenovirus, and similar to quail bronchitis virus. Synonym: chicken embryo lethal orphan virus. (05 Mar 2000) |
| minimal lethal dose | <pharmacology> The minimal dose of a toxic substance or infectious agent that is lethal, as assayed in various experimental animals (e.g., the least amount of diphtheria toxin that, on an average, kills a 250-g guinea pig within 96 hours after subcutaneous inoculation). When followed by a subscript (generally "MLD50"), denotes the minimal dose that is lethal to a certain percentage (e.g., 50%) of animals so assayed, LD05. See: lethal dose. (05 Mar 2000) |
| clinical lethal | A disorder that culminates in premature death. (05 Mar 2000) |
| conditional-lethal mutant | A viral mutant that can replicate under some (permissive) conditions but not under other (restrictive or nonpermissive) conditions, the parent (wild type) strain being able to replicate under both conditions. See: suppressor-sensitive mutant, temperature-sensitive mutant. Synonym: conditional-lethal mutant. (05 Mar 2000) |
| conditionally lethal mutant | A viral mutant that can replicate under some (permissive) conditions but not under other (restrictive or nonpermissive) conditions, the parent (wild type) strain being able to replicate under both conditions. See: suppressor-sensitive mutant, temperature-sensitive mutant. Synonym: conditional-lethal mutant. (05 Mar 2000) |
| y-suppressed lethal gene | <genetics> In the fruit fly Drosophila, this is a recessive, lethal gene that kills XO flies but not normal XY male flies. (09 Oct 1997) |
| zygotic lethal gene | <genetics> A mutated or otherwise defective gene at embryonic or larval stages. (06 May 1997) |
| lethal | Deadly, fatal. Origin: L. Lethalis, from lethum = death (18 Nov 1997) |