| toxic multinodular goiter | Condition in which the thyroid gland contains multiple lumps (nodules) that are overactive, produce excess thyroid hormones and thereby cause hyperthyroidism. This condition is also known as parry's disease or plummer's disease. (12 Dec 1998) |
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| toxic nephrosis | Acute oliguric renal failure due to chemical poisons, septicaemia, or bacterial toxaemia; frequently associated with extensive necrosis of proximal convoluted tubules. (05 Mar 2000) |
| toxic neuritis | Neuritis caused by an endogenous or exogenous toxin. (05 Mar 2000) |
| toxic nodular goitre | <endocrinology> An enlarged thyroid gland which contains nodules which release excess thyroid hormone. This condition usually arises from long-standing simple goitre in the elderly. Symptoms of hyperthyroidism result. (12 Jan 1998) |
| toxic psychosis | A psychosis caused by some toxic substance, whether endogenous or exogenous. (05 Mar 2000) |
| toxic retinopathy | Retinal changes due to prolonged administration of various drugs. (05 Mar 2000) |
| toxic shock | See toxic shock syndrome. (12 Dec 1998) |
| toxic shock syndrome | <syndrome> A blood-borne bacterial infection caused by the genus Staphylococcus. Usually effects menstruating females under the age of thirty and was associated in the past with the use of a particular type of tampon (no longer used). Common symptoms include: fever, chills, vomiting, sore throat, headache and decreased urine output. Progression of disease can result in lowering of blood pressure (shock) and renal failure. Treatment includes hospitalisation and intravenous antibiotics emergently. (27 Sep 1997) |
| toxic substances | A chemical or mixture of chemicals that presents a high risk of injury to human health or to the environment. (05 Dec 1998) |
| toxic tetanus | Tonic spasms caused by strychnine or other tetanic. Synonym: toxic tetanus. (05 Mar 2000) |
| toxic unit | A unit formerly synonymous with minimal lethal dose but which, because of the instability of toxins, is now measured in terms of the quantity of standard antitoxin with which the toxin combines. See: L doses, minimal lethal dose. Synonym: toxin unit. (05 Mar 2000) |
| epidermal necrolysis, toxic | An exfoliative disease of skin seen primarily in adults and characterised by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. (12 Dec 1998) |
| abscopal effect | A reaction produced following irradiation but occurring outside the zone of actual radiation absorption. (05 Mar 2000) |
| additive effect | <biochemistry, chemistry> An additive effect is the overall biological effect two chemicals acting together and which is the simple sum of the effects of the chemicals acting independently. Compare: antagonism. (15 Jan 1998) |
| adverse effect | This is an abnormal or harmful effect to an organism caused by exposure to a chemical. It is indicated by some result such as death, a change in food or water consumption, altered body and organ weights, altered enzyme levels, or visible illness. An effect may be classed as adverse if it causes functional or anatomical damage, causes irreversible change in the homeostasis of the organism, or increases the susceptibility of the organism to other chemical or biological stress. A non-adverse effect will usually be reversed when the organism is no longer being exposed to the chemical. (09 Oct 1997) |