| ELECTZ | electrosurgical loop excision of the cervical transformation zone |
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| HLT | heart-lung transplantation; human lipotropin; human lymphocyte transformation |
| LETS | large external transformation-sensitive [protein] |
| LLETZ | large loop excision of the transformation zone |
| LTT | lactose tolerance test; leucine tolerance test; limited treadmill test; lymphocyte transformation te... |
| refractory rickets | Rickets that does not respond to treatment with usual doses of vitamin D and adequate dietary calcium and phosphorus. Most often due to inherited renal tubular disorder e.g., Fanconi syndrome. Renal rickets, a form of rickets occurring in children in association with and apparently caused by renal disease with hyperphosphatemia. Synonym: pseudorickets, renal fibrocystic osteosis, renal infantilism, renal osteitis fibrosa. (05 Mar 2000) |
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| refractory state | Subnormal excitability immediately following a response to previous excitation; the state is divided into absolute and relative phases. (05 Mar 2000) |
| relative refractory period | The period between the effective refractory period and the end of the refractory period; fibres then respond only to high intensity stimuli and the impulses conduct more slowly than normally. (05 Mar 2000) |
| effective refractory period | The period during which impulses may appear but are too weak to be conducted; the longest interval between adequate stimuli, falling just short of the time necessary to allow a propagated response to be evoked in a tissue by the second stimulus; it differs from the functional refractory period in that it is a measure of stimulus interval rather than response interval of time. (05 Mar 2000) |
| total refractory period | The absolute refractory period plus the relative refractory period. (05 Mar 2000) |
| functional refractory period | The minimum interval possible between successive responses to stimulation of a tissue. (05 Mar 2000) |
| abiotic transformation | <biochemistry> An abiotic transformation is any process in which a chemical in the environment is altered by non-biological mechanisms (such as by exposure to sunlight). (09 Oct 1997) |
| bacterial transformation | <microbiology> A genetics lab procedure where bacteria are induced to accept and incorporate into their genome foreign pieces of cell-less, isolated DNA, often in the form of a plasmid. The DNA to be introduced usually contains a selectable marker so that the bacteria which successfully incorporate the DNA can be selected for. (09 Oct 1997) |
| blast transformation | <haematology> The morphological and biochemical changes in lymphocytes, both B and T, on exposure to antigen or to a mitogen. The cells appear to move from G0 to G1 stage of the cell cycle. They usually enlarge and proceed to S phase and mitosis later. The process probably involves receptor cross linking on the plasma membrane. (18 Nov 1997) |
| genetic transformation | <molecular biology> Genetic change brought about by the introduction of exogenous DNA into a cell. See: transformation, germ line transformation, transfection. (18 Nov 1997) |
| germ line transformation | Micro injection of foreign DNA into an early embryo, so that it becomes incorporated into the germ line of the individual and thus stably inherited in subsequent generations of transgenic organisms. Typically, the DNA would be a reporter gene or cDNA in a vector such as a transposon, that might also carry a visible marker gene such as eye or coat colour), so that successful transformation could readily be detected. (18 Nov 1997) |
| viral transformation | <oncology, virology> Malignant transformation of an animal cell in culture, induced by a virus. (18 Nov 1997) |
| cell transformation | Morphological and physiological changes resulting from infection of an animal cell by an oncogenic virus. (05 Mar 2000) |
| cell transformation, neoplastic | Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. (12 Dec 1998) |
| cell transformation, viral | An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. (12 Dec 1998) |