| Ehrlich, Paul | <person> A brilliant scientist and student, born in Silesia, Germany, who at the age of 23 published his first scientific paper which was on the discovery of the mast cells - a name coined by him (1887). While a resident in medicine at Charite Hospital in Berlin he utilised the newly discovered aniline dyes to develop some of the basic methods of histology. Among his contributions are: The preparation and staining of blood smears, he demonstrated granules in leukocytes, described the neutrophil, basophil, eosinophil, myelocyte, and mononuclear cells (white blood cells), he demonstrated normoblasts, megaloblasts and microblasts of the erythrocytic (red blood cell) series. In 1887, he differentiated lymphocytic leukaemia from "bone marrow leukaemia" (myeloid) on blood smear, in 1888, he described aplastic anaemia, in 1882 the diazo reaction of typhoid urines, in 1882, less than six weeks after Koch described the Tuberculus bacillus, Ehrlich had described its acid-fastness and devised the fuchsin stain to demonstrate the pink rod on a blue background. Ehrlich fell ill with tuberculosis and went to Egypt for 3 years for rest and cure. Following his return, he entered the field of immunology. at Von Behring's request, he developed means of standardising antitoxin dosage (immunization units). at the age of 42, he became director of the "Royal Institute for Standardisation and Investigation of Antitoxic Sera." Here he devised his famous "side-chain" theory of immunisation. It has since been replaced. Paul Ehrlich reinvestigated Bordet's alexin and heat-stable substance and named them "complement" and "immune body". Ehrlich coined the terms and created a new science of chemotherapy. In 1910 he discovered Salvarsan or 606, a therapeutic antiluetic. For his silver bullet (Salvarsan) in 1908, he received the Nobel Prize. This scientist was greatly concerned over the problem of drug fastness which still remains a problem. He died August 20, 1915. Lived: 1854-1915. (18 Nov 1997) |
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| Trenaunay, Paul | <person> French physician, *1875. See: Klippel-Trenaunay-Weber syndrome. (05 Mar 2000) |
| Jacques, Paul | <person> 19th century French physician. See: Jacques' plexus. (05 Mar 2000) |
| Junius, Paul | <person> German ophthalmologist, *1871. See: Kuhnt-Junius degeneration, Kuhnt-Junius disease. (05 Mar 2000) |
| Yvon, Paul | Paul, French physician and chemist, 1848-1913. See: Yvon's test. (05 Mar 2000) |
| Unna, Paul | <person> German dermatologist and staining expert, 1850-1929. See: Unna's disease, Unna's mark, Unna's stain, Unna-Pappenheim stain, Unna-Taenzer stain. (05 Mar 2000) |
| Kraske, Paul | <person> German surgeon, 1851-1930. See: Kraske's operation. (05 Mar 2000) |
| Flechsig, Paul | <person> German neurologist, 1847-1929. See: Flechsig's areas, Flechsig's ground bundles, Flechsig's fasciculi, Flechsig's tract, oval area of Flechsig, semilunar nucleus of Flechsig. (05 Mar 2000) |
| Langerhans, Paul | <person> B. Berlin, July 25th, 1847. Was a Physician and an Anatomist and became Professor of Pathological Anatomy in Freiburg. On his retirement went to Madeira. D. Funchal, July 20th, 1888. Islets of Langerhans - collection of cells in the pancreas which produce insulin and glucagon. Cells of Langerhans - dendritic cells found in the epidermis of the skin. Lived: 1847-1888. (05 Dec 1998) |
| Abbe test plate | <equipment> A long, wedge-shaped coverslip about 0.20 mm thick at one end and 0.10 to 0.12 mm at the other end coated chemically with a silver film on which are ruled horizontal lines. at each variation in thickness of 0.01 mm there are vertical lines. By means of oblique illumination and by focusing on different portions of the plate, it is possible to determine the optimum coverslip thickness for any objective and also, for microscopes with drawtubes, the tube length for best objective performance. The approximate freedom from spherical and chromatic aberrations can also be estimated. Small isolated bits of silver near the edges of the lines form good objects for the star test (05 Aug 1998) |
| acetone test | A test for ketonuria; the suspected urine is shaken up with a few drops of sodium nitroprusside, and strong ammonia water is then gently poured over the mixture; if acetone is present, a magenta ring forms at the line of contact; tablets containing sodium nitroprusside and alkali are now more commonly used. (05 Mar 2000) |
| achievement test | A standardised test used to measure acquired learning, e.g., competence in a specific subject area such as reading or arithmetic, in contrast to an intelligence test which is a useful index of potential ability or learning. (05 Mar 2000) |
| acidified serum test | Lysis of the patient's red cells in acidified fresh serum, specific for paroxysmal nocturnal haemoglobinuria. Synonym: Ham's test. (05 Mar 2000) |
| acid loading test | <nephrology> This is a test used in the diagnosis of renal tubular acidosis. The patient takes ammonium chloride capsules for 3 days to acidify the blood (lower blood pH). A sample of the urine and the blood is then collected and the results are interpreted. (27 Sep 1997) |
| acid perfusion test | <gastroenterology, investigation> A test used to diagnosis gastrooesophageal reflux disease. This investigation requires that the patient swallow 3 tiny tubes into the stomach. A mixture of hydrochloric acid (like stomach acid) and saline are alternatively injected into the tubes. The patient then reports any symptoms they may have. Some patients may vomit. (13 Nov 1997) |