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Ornish d. a vegetarian diet containing 10 per cent of calories from fat and 5 mg cholesterol, used in combination with stress reduction techniques and moderate exercise for the prevention and treatment of cardiovascular disease.
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ornithine aminotransferase an enzyme of the transferase class that catalyzes the conversion of ornithine to Δ1-pyrroline 5-carboxylate via transfer of the ornithine amino group to an α-keto acid (e.g., α-ketoglutarate). The reaction is important in the degradation of ornithine from excess dietary tissue arginine, in the biosynthesis of proline, and in the de novo synthesis of ornithine. The enzyme is a mitochondrial matrix protein occurring in most cells; deficiency of it, an autosomal recessive trait, causes gyrate atrophy of choroid and retina. Abbreviated OAT. In EC nomenclature called ornithine–oxo-acid transaminase.
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ornithine c. urea c.
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ornithine carbamoyltransferase [EC 2.1.3.3] an enzyme of the transferase class that catalyzes the carbamoylation of ornithine by carbamoyl phosphate to form citrulline. The reaction occurs in liver mitochondria as part of the urea cycle (see illustration at urea cycle). Called also ornithine transcarbamoylase (OTC). Abbreviated OCT.
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ornithine carbamoyltransferase (OCT) deficiency an X-linked aminoacidopathy involving the biosynthesis of urea; most hemizygous males show complete deficiency and do not survive the neonatal period; heterozygous females show varying degrees of deficiency and age of onset. Characteristic signs include hyperammonemia, neurologic abnormalities, and oroticaciduria. Called also ornithine transcarbamoylase (OTC) deficiency.
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