perichondral cutaneous graft
| new england | The geographic area of new england in general and when the specific state or states are not indicated. States usually included in this region are maine, new hampshire, vermont, massachusetts, connecticut, and rhode island. (12 Dec 1998) |
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| new growth | <oncology, pathology> New and abnormal growth of tissue, which may be benign or cancerous. (16 Dec 1997) |
| new guinea | Originally an island of the malay archipelago, the second largest island in the world. It divided, west new guinea becoming part of indonesia and east new guinea becoming papua new guinea. (12 Dec 1998) |
| New Hampshire rule | Pioneering American test of criminal responsibility (1871): "if the [criminal] act was the offspring of insanity, a criminal intent did not produce it." (05 Mar 2000) |
| new methylene blue | A basic thiazin dye, C18H22N3SCl, used for supravital staining of reticulocytes in blood smears. (05 Mar 2000) |
| new mutation | Redundant term for a heritable trait present in the offspring but in neither parent, i.e., not a pre-existing mutant form inherited. (05 Mar 2000) |
| new south wales | A state in southeastern Australia. Its capital is sydney. It was discovered by captain cook in 1770 and first settled at botany bay by marines and convicts in 1788. It was named by captain cook who thought its coastline resembled that of south wales. (12 Dec 1998) |
| new yellow enzyme | The d-amino-acid oxidase found in yeast, a flavoenzyme, which contains FAD as coenzyme instead of FMN as does NADPH dehydrogenase; so-called to distinguish it from Warburg's old yellow enzyme. Compare: amino acid oxidases. (05 Mar 2000) |
| New York Heart Association classification | A functional classification to assess cardiovascular disability. Class I: patients with cardiac disease without limitation of physical activity. Ordinary activity does not cause symptoms. Class II: patients with cardiac disease with slight limitation of activity; comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnea or angina. Class III: patients with cardiac disease producing marked limitation of activity: comfortable at rest. Less than ordinary physical activity causes symptoms. Class IV: patients with cardiac disease resulting in inability to carry on any physical activity without discomfort. Symptoms may be present even at rest. (05 Mar 2000) |
| new zealand | A group of islands in the South Pacific Ocean. New Zealand flax. <botany> A myrtaceous shrub (Leptospermum scoparium) of new Zealand and Australia, the leaves of which are used as a substitute for tea. Source: Websters Dictionary (01 Mar 1998) |
| New Zealand mice | Inbred strains of mice, either black (NZB) or white (NZW), unique among strains used in experimental immunology because of their proclivity to spontaneous immunologic abnormalities and disorders including systemic lupus erythematosus similar to that found in humans. (05 Mar 2000) |
| investigational new drug | Status given an experimental drug after the FDA approves an application for testing it in people. (09 Oct 1997) |
| investigational new drug application | An application that must be submitted to a regulatory agency (the FDA in the united states) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (12 Dec 1998) |
| anergic leishmaniasis | Leishmaniasis caused by several New and Old World species and strains of Leishmania (L. Mexicana amazonensis, L. M. Pifanoi, possibly L. M. Garnhami and L. M. Venezuelensis; in Ethiopia, L. Aethiopica, and unidentified leishmanial agents in Namibia and Tanzania). The condition is associated with a suppressed cell-mediated immune response, so that the non-ulcerating, non-necrotizing cutaneous lesions can spread widely over the body; great numbers of parasite-filled macrophages are found in the dermal lesions. Healing does not appear to occur unless an acquired cellular hypersensitivity can develop. Synonym: anergic leishmaniasis, diffuse leishmaniasis, disseminated cutaneous leishmaniasis, leishmaniasis tegumentaria diffusa, pseudolepromatous leishmaniasis. (05 Mar 2000) |
| canine leishmaniasis | A mild infection of dogs, usually confined to the muzzle or ears, produced by human disease-causing species of Leishmania; dogs therefore are important reservoirs of human infection, such as with visceral leishmaniasis in the Mediterranean region. (05 Mar 2000) |