| toxic effect | <physiology> The physiologic, physical or laboratory manifestations or derangement that can be attributed to the presence of a substance within the body. (12 Jan 1998) |
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| toxic epidermal necrolysis | A syndrome in which a large portion of the skin becomes intensely erythematous with epidermal necrosis, and peels off in the manner of a second-degree burn, often simultaneous with the formation of flaccid bullae, resulting from drug sensitivity or of unknown cause; the level of separation is subepidermal, unlike staphylococcal scalded skin syndrome in which there is subcorneal change. Synonym: Lyell's syndrome. (05 Mar 2000) |
| toxic equivalent | The amount of toxin or other poison per kilogram of body weight necessary to kill an animal. (05 Mar 2000) |
| toxic goiter | A goiter that forms an excessive secretion, causing signs and symptoms of hyperthyroidism. (05 Mar 2000) |
| toxic haemoglobinuria | Haemoglobinuria occurring after the ingestion of various poisons, in certain blood diseases, and in certain infections. (05 Mar 2000) |
| toxic hydrocephalus | Thrombotic hydrocephalus associated with some general infection or toxic state. (05 Mar 2000) |
| toxic megacolon | <gastroenterology, surgery> An acute nonobstructive dilation of the colon, seen in advanced ulcerative colitis and Crohn's disease. (12 Jan 1998) |
| toxic multinodular goiter | Condition in which the thyroid gland contains multiple lumps (nodules) that are overactive, produce excess thyroid hormones and thereby cause hyperthyroidism. This condition is also known as parry's disease or plummer's disease. (12 Dec 1998) |
| toxic nephrosis | Acute oliguric renal failure due to chemical poisons, septicaemia, or bacterial toxaemia; frequently associated with extensive necrosis of proximal convoluted tubules. (05 Mar 2000) |
| toxic neuritis | Neuritis caused by an endogenous or exogenous toxin. (05 Mar 2000) |
| toxic nodular goitre | <endocrinology> An enlarged thyroid gland which contains nodules which release excess thyroid hormone. This condition usually arises from long-standing simple goitre in the elderly. Symptoms of hyperthyroidism result. (12 Jan 1998) |
| toxic psychosis | A psychosis caused by some toxic substance, whether endogenous or exogenous. (05 Mar 2000) |
| toxic retinopathy | Retinal changes due to prolonged administration of various drugs. (05 Mar 2000) |
| toxic shock | See toxic shock syndrome. (12 Dec 1998) |
| toxic shock syndrome | <syndrome> A blood-borne bacterial infection caused by the genus Staphylococcus. Usually effects menstruating females under the age of thirty and was associated in the past with the use of a particular type of tampon (no longer used). Common symptoms include: fever, chills, vomiting, sore throat, headache and decreased urine output. Progression of disease can result in lowering of blood pressure (shock) and renal failure. Treatment includes hospitalisation and intravenous antibiotics emergently. (27 Sep 1997) |