| malignant ciliary epithelioma | <tumour> Malignant hyperplasia of ciliary epithelium with frequent involvement of the pigmented layer. Synonym: adult medulloepithelioma. (05 Mar 2000) |
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| malignant dysentery | Dysentery in which the symptoms are intensely acute, leading to prostration, collapse, and often death. Synonym: fulminating dysentery. (05 Mar 2000) |
| malignant dyskeratosis | Dyskeratosis that may occur in precancerous or malignant lesions. (05 Mar 2000) |
| malignant endocarditis | Acute bacterial endocarditis, usually secondary to suppuration elsewhere and running a fulminating course. Synonym: septic endocarditis. (05 Mar 2000) |
| malignant exophthalmos | Relentless, progressive protrusion of the eyeballs. (05 Mar 2000) |
| malignant fibrous histiocytoma | <tumour> A deeply situated tumour, especially on the extremities of adults, frequently recurring after surgery and metastasizing to the lungs; shows partial fibroblastic and histiocytic differentiation with a variable storiform pattern, myxoid areas, and giant cells. (05 Mar 2000) |
| malignant giant cell tumour | A type of bone tumour. (12 Dec 1998) |
| malignant glaucoma | Secondary glaucoma caused by forward displacement of the iris and lens, obliterating the anterior chamber; usually follows a filtering operation for primary glaucoma. (05 Mar 2000) |
| malignant granuloma | Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases. An obsolete term for polymorphic reticulosis. Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma. (05 Mar 2000) |
| malignant hepatoma | <tumour> A carcinoma derived from parenchymal cells of the liver. Synonym: hepatocarcinoma, hepatocellular carcinoma, liver cell carcinoma. (05 Mar 2000) |
| malignant histiocytosis | A rapidly fatal form of lymphoma, characterised by fever, jaundice, pancytopenia, and enlargement of the liver, spleen, and lymph nodes; the affected organs show focal necrosis and haemorrhage, with proliferation of histiocytes and phagocytosis of red blood cells. (05 Mar 2000) |
| malignant hyperphenylalaninaemia | DHPR-deficient form; an inherited disorder in which there is an absence or deficiency of dihydropteridine reductase (DHPR); this results in impaired regeneration of tetrahydrobiopterin, causing an elevation in phenylalanine levels, GTP-CH form; an inherited disorder in which there is a deficiency of guanosine triphosphate cyclohydrolase, an enzyme used in the biosynthesis of tetrahydrobiopterin, 6-PTS form; an inherited disorder in which there is a deficiency of 6-pyruvoyl tetrahydropterin synthase, an enzyme that participates in the biosynthesis of tetrahydrobiopterin. Synonym: nonclassical phenylketonuria. (05 Mar 2000) |
| malignant hyperpyrexia | A severe and often fatal illness produced by exposure to excessively high temperatures, especially when accompanied by marked exertion. It can manifest by elevated body temperature, lack of sweating, hot dry skin, and neurologic symptoms; unconsciousness, paralysis, headache, vertigo, confusion. In severe cases very high fever, vascular collapse, and coma develop. Synonym: heat apoplexy, heat hyperpyrexia, malignant hyperpyrexia, thermic fever. (05 Mar 2000) |
| malignant hypertension | A severe form of acute hypertension that results in the abrupt rise in the blood pressure (diastolic pressure often over 120 mmHg). If left untreated, malignant hypertension can cause damage to the blood vessels in the eye, kidneys, brain and heart. Complications include stroke, heart attack, blindness and renal failure. Symptoms include headache, blurred vision, nausea, vomiting and lethargy. Neurologic symptoms are also a common finding. Malignant hypertension occurs more commonly in males, African Americans and those with a history for hypertension. (27 Sep 1997) |
| malignant hyperthermia | A severe form of fever that occurs as a reaction to certain anaesthetic agents and muscle relaxants. Malignant hyperthermia is an inherited autosomal dominant condition. Inheritance: autosomal dominant. (27 Sep 1997) |