| lupus erythematosus, systemic | A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterised principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown aetiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of le cells in the blood or bone marrow. (12 Dec 1998) |
|---|---|
| lupus glomerulonephritis-pathology | Patient survival and preservation of renal function are predictable from renal pathology as demonstrated by biopsy and defined by the histological classification of the International Study of Kidney Disease in Children/World Health Organization (ISKDC/WHO). Semi-quantitative indices of nephron loss (chronicity index) and activity of acute potentially reversible inflammation (activity index) are not predictive of individual outcome, renal failure or death in patients with aggressively treated SLE GN. (05 Mar 2000) |
| lupus livido | Persistent cyanotic lesions on the extremities, associated with the cutaneous manifestations of Raynaud's disease. (05 Mar 2000) |
| lupus lymphaticus | A congenital nevoid lesion consisting of a circumscribed group of tense lymph vesicles. Synonym: lupus lymphaticus, lymphangiectodes, lymphangioma capillare varicosum, lymphangioma superficium simplex. (05 Mar 2000) |
| lupus miliaris disseminatus faciei | A millet-like papular eruption of the face, associated with a (histopathologically) tuberculoid perifollicular infiltration, but probably related to rosacea rather than tuberculous infection. (05 Mar 2000) |
| lupus mutilans | Cutaneous tuberculosis with extensive destruction of tissue. (05 Mar 2000) |
| lupus nephritis | Glomerulonephritis associated with systemic lupus erythematosus. It is classified into four histologic types: mesangial, focal, diffuse, and membranous. (12 Dec 1998) |
| lupus papillomatosus | A tuberculous skin lesion having a warty surface with a chronic inflammatory base seen on the hands in adults and lower extremities in children, with marked hypersensitivity to tuberculous antigens. See: postmortem wart. Synonym: lupus papillomatosus, lupus verrucosus, tuberculous wart, verrucous scrofuloderma. (05 Mar 2000) |
| lupus pernio | Sarcoid lesions, clinically resembling frostbite and microscopically resembling lupus vulgaris, involving ears, cheeks, nose, hands, and fingers. (05 Mar 2000) |
| lupus profundus | A subcutaneous panniculitis with marked lymphocyte infiltration of fat lobules giving rise to deep-seated, firm, rubbery nodules that sometimes become ulcerated, usually of the face; may occur in systemic and localised lupus erythematosus. Synonym: lupus profundus. (05 Mar 2000) |
| lupus sebaceus | Lupus erythematosus with lesions on the face in butterfly areas. (05 Mar 2000) |
| lupus serpiginosus | A cutaneous tuberculous lesion that spreads peripherally, healing centrally with scar formation. (05 Mar 2000) |
| lupus superficialis | Skin disease in which there are red scaly patches, especially over the nose and cheeks. May be a symptom of systemic lupus erythematosus. (18 Nov 1997) |
| lupus tuberculosus | Cutaneous tuberculosis with characteristic nodular lesions on the face, particularly about the nose and ears. Synonym: lupus tuberculosus, tuberculosis cutis luposa. (05 Mar 2000) |
| lupus verrucosus | A tuberculous skin lesion having a warty surface with a chronic inflammatory base seen on the hands in adults and lower extremities in children, with marked hypersensitivity to tuberculous antigens. See: postmortem wart. Synonym: lupus papillomatosus, lupus verrucosus, tuberculous wart, verrucous scrofuloderma. (05 Mar 2000) |