| united states office of research integrity | An office of the united states public health service organised in june 1992 to promote research integrity and investigate misconduct in research supported by the public health service. It consolidates the office of scientific integrity of the national institutes of health and the office of scientific integrity review in the office of the assistant secretary for health. The ori is in the office of the assistant secretary for health and its director reports directly to the assistant secretary for health, department of health and human services. (ri newsletter, 1993 jan; 1(1):1) (12 Dec 1998) |
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| adenine nucleotide | A condensation product of adenosine and phosphoric acid; a nucleotide found among the hydrolysis products of all nucleic acids. 3'-Adenylic acid (adenosine 3'-monophosphate) and 5'-adenylic acid (adenosine 5'-monophosphate) differ in the place of attachment of the phosphoric acid to the d-ribose; deoxyadenylic acid differs in having H instead of OH at the 2' position of d-ribose. See: AMP. Synonym: adenine nucleotide. (05 Mar 2000) |
| adenine nucleotide translocase | <enzyme> Catalyses the exchange between endogenous and exogenous adenine nucleotides in mitochondria.ec 2.7.7.-. Registry number: EC 2.7.7.- (12 Dec 1998) |
| xanthine nucleotide | The monophosphoric ester of xanthosine. An intermediate in GMP biosynthesis. Synonym: xanthidylic acid, xanthine nucleotide, xanthylic acid. (05 Mar 2000) |
| pyrimidine-5'-nucleotide nucleosidase | <enzyme> Also acts on some deoxyribonucleotides Registry number: EC 3.2.2.10 Synonym: pyr-5'-nt-nucleosidase (26 Jun 1999) |
| nicotinamide-nucleotide adenylyltransferase | <enzyme> An enzyme that catalyses reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of nmn to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyses the final reaction in the major pathway for the biosynthesis of NAD in mammals. Chemical name: ATP:nicotinamide-nucleotide adenylyltransferase Registry number: EC 2.7.7.1 (12 Dec 1998) |
| nucleotide | <biochemistry> Phosphate esters of nucleosides. The metabolic precursors of nucleic acids are monoesters with phosphate on carbon 5 of the pentose (known as 5' to distinguish sugar from base numbering). However many other structures, such as adenosine 3'5' cyclic monophosphate (cAMP) and molecules with 2 or 3 phosphates are also called nucleotides. (18 Nov 1997) |
| nucleotide binding fold | Protein motif consisting of a fold or pocket with certain conserved residues, required for the binding of nucleotides. (18 Nov 1997) |
| nucleotide deaminases | <enzyme> Catalyze the hydrolysis of nucleotides with the elimination of ammonia. Registry number: EC 3.5.4 (12 Dec 1998) |
| nucleotide deletion | Deletion of a single nucleotide, which in a transcribed gene will lead to a frameshift mutation. Synonym: point deletion. (05 Mar 2000) |
| nucleotide mapping | Two-dimensional separation and analysis of nucleotides. (12 Dec 1998) |
| nucleotide pair | <molecular biology> Two nitrogenous bases (adenine and thymine or guanine and cytosine) held together by weak bonds. Two strands of DNA are held together in the shape of a double helix by the bonds between base pairs. (09 Oct 1997) |
| nucleotide phosphotransferase | <enzyme> Transfers phosphoric acid from an organic phosphate donor to the 2' or 3' hydroxyls of nucleosides and nucleotides Registry number: EC 2.7.1.- (26 Jun 1999) |
| nucleotide pyrophosphate transferase | <enzyme> Transfers the beta, gamma pyrophosphate group from ATP to 3'-hydroxy group of ribonucleotides, oligonucleotides or trna Registry number: EC 2.7.6.- (26 Jun 1999) |
| diphosphopyridine nucleotide | nAD |