| generalised chondromalacia | A degenerative disease of cartilage producing a bizarre form of arthritis, with collapse of the ears, the cartilaginous portion of the nose, and the tracheobronchial tree; death may occur from chronic infection or suffocation because of loss of stability in the tracheobronchial tree of autosomal origin. Synonym: chronic atrophic polychondritis, generalised chondromalacia, Meyenburg's disease, Meyenburg-Altherr-Uehlinger syndrome, relapsing perichondritis, systemic chondromalacia, von Meyenburg's disease. (05 Mar 2000) |
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| generalised cortical hyperostosis | <syndrome> An inherited skeletal dysplasia, with mandibular enlargement and thickening of the diaphyses and calvaria, and increased serum alkaline phosphatase; autosomal recessive inheritance. Synonym: generalised cortical hyperostosis. (05 Mar 2000) |
| generalised elastolysis | A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (12 Dec 1998) |
| generalised emphysema | Emphysema affecting all parts of the lobules, in part, or usually the whole, of the lungs, and usually associated with a1-antiprotease deficiency emphysema. Synonym: diffuse emphysema, generalised emphysema, panacinar emphysema. (05 Mar 2000) |
| generalised epidermolytic hyperkeratosis | Diffusely red, eroded skin at birth, with subsequent scaling, tending to improve in later life, characterised by generalised epidermolytic hyperkeratosis and autosomal dominant inheritance. See: epidermolytic hyperkeratosis. Synonym: generalised epidermolytic hyperkeratosis, ichthyismus hystrix, ichthyosis hystrix. (05 Mar 2000) |
| generalised epilepsy | A major category of epilepsy syndromes characterised by one or more types of generalised seizures. (05 Mar 2000) |
| generalised eruptive histiocytoma | A rare recurring generalised eruption in adults of flesh coloured or erythematous papules remaining localised to the skin and consisting of dermal nodules of mononuclear histiocytes that do not stain for lipid. Synonym: nodular non-X histiocytosis. (05 Mar 2000) |
| generalised gangliosidosis | Three forms exist: infantile, generalised; juvenile; and adult; gangliosidosis characterised by accumulation of a specific monosialoganglioside, GM1; due to deficiency of GM1-beta-galactosidase. Synonym: generalised gangliosidosis. (05 Mar 2000) |
| generalised glycogenosis | Glycogenosis due to lysosomal alpha-1,4-glucosidase deficiency, resulting in accumulation of excessive amounts of glycogen of normal chemical structure in heart, muscle, liver, and nervous system. Synonym: generalised glycogenosis, Pompe's disease. (05 Mar 2000) |
| generalised myokymia | Widespread myokymia, present in multiple limbs and often the face; of various causes, including Isaac's syndrome, uraemia, thyrotoxicosis and gold toxicity (gold-myokymia syndrome). (05 Mar 2000) |
| generalised paralysis | Paralysis of both whole sides of the body; survival is usually of short duration. Synonym: generalised paralysis. (05 Mar 2000) |
| generalised pustular psoriasis of Zambusch | An extensive exacerbation of psoriasis, with pustule formation in the normal and psoriatic skin, fever, and granulocytosis; sometimes precipitated by oral steroids. Synonym: generalised pustular psoriasis of Zambusch. A local pustular eruption of the palms and soles, occurring most commonly in a patient with psoriasis; difficult to distinguish from acrodermatitis continua. (05 Mar 2000) |
| generalised seizure | <neurology> A type of seizure that results in loss of consciousness, generalised muscle contractions, urinary incontinence, tongue biting and a post-ictal state (confusion and lethargy) following cessation of the seizure. Synonym: grand-mal seizure. See: epilepsy. (03 Jul 1999) |
| generalised seizures | Seizures characterised by generalised cerebral onset clinically and on EEG. (05 Mar 2000) |
| generalised Shwartzman phenomenon | When both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread haemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunological basis. Synonym: Sanarelli phenomenon, Sanarelli-Shwartzman phenomenon. (05 Mar 2000) |