| protocatechuate-3,4-dioxygenase | <enzyme> An enzyme that catalyses the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. Chemical name: Protocatechuate:oxygen 3,4-oxidoreductase (decyclizing) Registry number: EC 1.13.11.3 (12 Dec 1998) |
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| homogentisate 1,2-dioxygenase | An iron-containing enzyme that catalyses the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria. Synonym: homogentisic acid oxidase. (05 Mar 2000) |
| hydroxyquinol 1,2-dioxygenase | <enzyme> Catalyses oxidative ring fission of hydroxyquinol to yield 3-hydroxy-cis,cis-muconate; contains ferric iron; specific for hydroxyquinol Registry number: EC 1.13.11.- Synonym: 1,2,4-trihydroxybenzene 1,2-dioxygenase (26 Jun 1999) |
| hyoscyamine (6S)-dioxygenase | <enzyme> A 2-oxoglutarate-dependent dioxygenase that catalyses hydroxylation of l-hyoscyamine to 6beta-hydroxyhyoscyamine in biosynthetic pathway to scopolamine; requires fe2+ Registry number: EC 1.14.11.11 Synonym: hyoscyamine 6beta-hydroxylase, hyoscyamine 6 beta-hydroxylase (26 Jun 1999) |
| naphthalene dioxygenase | <enzyme> Forms cis-(1r,2s)-dihydroxy-1,2-dihydronaphthalene; requires NADH Registry number: EC 1.14.12.- (26 Jun 1999) |
| dioxin dioxygenase | <enzyme> Catalyses initial step of the degradations of dibenzofuan and dibenzo-p-dioxin; isolated from sphingomonas Registry number: EC 1.14.99.- (26 Jun 1999) |
| dioxygenase | An oxidoreductase that incorporates two atoms of oxygen (from one molecule of O2) into the (reduced) substrate. (05 Mar 2000) |
| isopropylbenzene dioxygenase | <enzyme> Pseudomonas putida enzyme; forms 2,3-dihydro-2,3-dihydroxyisopropylbenzene Registry number: EC 1.13.11.- Synonym: isopropylbenzene 2,3-dioxygenase, cumene 2,3-dioxygenase (26 Jun 1999) |
| ortho-halobenzoate 1,2-dioxygenase | <enzyme> A three-component broad substrate-specific enzyme that requires oxygen, NADH, fe(ii) and flavin adenine dinucleotide; degrades 2,4-, 2,5-dichloro-, 2-chloro (& a variety of other substituted halobenzoates) to 4-chlorocatechol and catechol Registry number: EC 1.14.12.- (26 Jun 1999) |
| terephthalate 1,2-dioxygenase | <enzyme> Converts terephthalate to (1r,2s)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid and protocatechuate; has 2 components, r (reductase) and z (oxygenase); from comamonas testosteroni; partial amino acid sequence given in first source Registry number: EC 1.- Synonym: ter-1,2-dioxygenase (26 Jun 1999) |
| thymine, 2-oxoglutarate dioxygenase | <enzyme> 5-hydroxymethyluracil,2-oxoglutarate dioxygenase was formerly EC 1.14.11.5; for this activity, substrate thymine may be replaced by uracil/analogs Chemical name: 5-hydroxymethyluracil,2-oxoglutarate dioxygenase /od/ thymine 7-hydroxylase Registry number: EC 1.14.11.6 Synonym: thymine 7-hydroxylase, alpha-ketoglutarate dioxygenase, thymine (26 Jun 1999) |
| toluene dioxygenase | <enzyme> Resolved into 3 protein components; maximum activity dependent on presence of ferrous iron and NADH; forms benzyl alcohol Registry number: EC 1.14.- Synonym: toluate oxygenase, toluate 1,2-dioxygenase (26 Jun 1999) |
| tryptophan 2,3-dioxygenase | An oxidoreductase catalyzing the reaction of l-tryptophan and O2 to produce l-N-formylkynurenine; an adaptive enzyme, the level (in the liver) being controlled by adrenal hormones; a step in tryptophan catabolism; also, a step in the synthesis of NAD+ from tryptophan. Synonym: pyrrolase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase. (05 Mar 2000) |
| 2,2',3-trihydroxybiphenyl dioxygenase | <enzyme> Key enzyme in the degradation pathways of dibenzo-p-dioxin and dibenzofuran; responsible for meta cleavage of the first aromatic ring Registry number: EC 1.13.11.- Synonym: 2,2',3-thbp dioxygenase (26 Jun 1999) |
| 2,3-dihydroxy-4-cumate-3,4-dioxygenase | <enzyme> Meta-cleavage enzyme involved in bacterial degradation of p-cymene; forms 3-carboxy-2-hydroxy-7-methyl-6-oxo-octa-2,3-dienoic acid from p-cymene; also acts on 2,3-dihydroxybenzoate, 3-methylcatechol, 3-isopropylcatechol and 2,3-dihydroxy-p-toluate; enzyme c of p-cumate catabolic pathway in pseudomonas putida Registry number: EC 1.13.11.- Synonym: 2,3-dihydroxy-p-cumate-3,4-dioxygenase, dhcumate dioxygenase, cmtc gene product (26 Jun 1999) |