| 1-deoxynojirimycin | <chemical> (2r-(2 alpha,3 beta,4 alpha,5 beta))-2-(hydroxymethyl)-3,4,5-piperidinetriol. An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. Pharmacological action: antiviral agents, enzyme inhibitors. Chemical name: 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))- (12 Dec 1998) |
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| 1-ene-dehydrogenase | <enzyme> Converts testosterone to 1-dehydrotestosterone in the absence of nad Registry number: EC 1.3.- Synonym: monocresyl diphenyl phosphate (26 Jun 1999) |
| 1-hexadecanol | The 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti; it is used as an emulsifying aid and in the preparation of "washable" ointment bases. Synonym: 1-hexadecanol, palmityl alcohol. (05 Mar 2000) |
| 1-methyl-3-isobutylxanthine | <chemical> 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-2,6-dione. A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates cyclic nucleotide-dependent protein kinases. Pharmacological action: phosphodiesterase inhibitors. Chemical name: 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- (12 Dec 1998) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | <chemical> 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine. A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in parkinson disease. These toxic effects can be prevented by the administration of selective monoamine oxidase inhibitors. Since the cellular toxicity of the compound is similar to that observed in idiopathic parkinson disease, experimental studies with this compound can suggest new opportunities for effective therapy. The compound also induces duodenal ulcers. Pharmacological action: dopamine agents. Chemical name: Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl- (12 Dec 1998) |
| 1-methyl-4-phenylpyridinium | <chemical> 1-methyl-4-phenylpyridinium (mpp+). An active neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to paraquat, has also been used as an herbicide. Pharmacological action: dopamine agents, herbicides. Chemical name: Pyridinium, 1-methyl-4-phenyl- (12 Dec 1998) |
| 1-naphthylamine | <chemical> 1-naphthalenamine. A suspected industrial carcinogen (and listed as such by osha). Its n-hydroxy metabolite is strongly carcinogenic and mutagenic. Pharmacological action: carcinogens. Chemical name: 1-Naphthalenamine (12 Dec 1998) |
| 1-naphthylisothiocyanate | <chemical> 1-isothiocyanatonaphthalene. A tool for the study of liver damage which causes bile stasis and hyperbilirubinaemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage. Chemical name: Naphthalene, 1-isothiocyanato- (12 Dec 1998) |
| 1-nitropyrene reductase | <enzyme> Nadh or NADPH can serve as reducing agent to form 1-aminopyrene Registry number: EC 1.7.- Synonym: 1-nitropyrene nitroreductase (26 Jun 1999) |
| 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase | <enzyme> Alkylacylglycerophosphorylethanolamine alk-1-enylacyl-glycerophosphorylethanolamine (ethanolamine plasmalogen) type of reaction (cis-olefination), cofactor requirement resembles fatty acid desaturases Registry number: EC 1.14.99.- (26 Jun 1999) |
| 1-octanol | <chemical> A colourless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticisers. Pharmacological action: solvents. (12 Dec 1998) |
| 1-phosphatidylinositol 3-kinase | <enzyme> An enzyme that catalyses the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, v(d)j recombination and cell cyle checkpoints.37. Chemical name: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase Registry number: EC 2.7.1.137 (12 Dec 1998) |
| 1-phosphatidylinositol 4-kinase | <enzyme> An enzyme that catalyses the conversion of phosphatidylinositol to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Chemical name: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate Registry number: EC 2.7.1.67 (12 Dec 1998) |
| 1-phosphofructaldolase | <enzyme> An enzyme of the lyase class that catalyses the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3s,4r)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (enzyme nomenclature, 1992) e.c. 4.1.2.13. Chemical name: D-Fructose-1,6-biphosphate D-glyceraldehyde-3-phosphate-lyase Registry number: EC 4.1.2.13 (12 Dec 1998) |
| 1-phosphofructokinase | <enzyme> From rhodobacter capsulatus fruk gene; catalyses d-fructose 1-phosphate to yield d-fructose 1,6-bisphosphate in presence of ATP; itp, GTP and utp can replace ATP Registry number: EC 2.7.1.56 Synonym: fructose 1-phosphate kinase, fruk gene product, phosphofructo-1-kinase (26 Jun 1999) |