| complement 1s | <enzyme> The activated form of complement 1 which has hydrolase activity. In the classical pathway, it splits first c4 and then c2 into active components, thereby generating a new enzyme referred to as eac142 or c42 or c3 convertase. Registry number: EC 3.4.21.42 (12 Dec 1998) |
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| complement 2 | The third component in the complement reaction sequence. It is a beta-globulin with a molecular weight of 117,000, a serum concentration of 30 micrograms/ml and a sedimentation coefficient of 4. It activates c3. (12 Dec 1998) |
| complement 3 | The fourth component to attach in the complement reaction sequence. It is a beta-globulin with a sedimentation coefficient of 5.5, a molecular weight of 185,000 and a serum concentration of 1.3 micrograms/ml. Its fragments have anaphylatoxic, chemotactic, and histaminic action and affect smooth muscle. (12 Dec 1998) |
| complement 3 convertase | <enzyme> The enzyme which in both the classical and alternate complement pathways cleaves complement 3 into anaphylatoxin (c3a) and c3b. Registry number: EC 3.4.21.43 (12 Dec 1998) |
| complement 3 nephritic factor | A magnesium-dependent IgG autoantibody found in serum of patients with chronic mesangioproliferative hypocomplementemic glomerulonephritis. It causes inactivation of c3 in the alternate pathway by cleaving c3 into two inactive fragments, c3c and c3d, instead of the normal c3b. (12 Dec 1998) |
| complement 3a | <chemical> Smaller fragment formed when c3 convertase splits c3 into c3a and c3b. C3a is a 77-amino acid peptide that includes a carboxy-terminal arginine which is crucial for its biological activities. C3a causes symptoms of immediate hypersensitivity (anaphylaxis) including smooth muscle contraction, mast cell histamine release, and local inflammation. It is considered an anaphylatoxin along with c4a, c5a, and c5a des-arginine. Chemical name: Complement C3a (12 Dec 1998) |
| complement 3b | <chemical> The larger fragment formed when c3 convertase splits c3 into c3a and c3b. In both the classical and alternate pathway, c3b participates in immune adherence and enhances phagocytosis. It also forms a cellular intermediate which continues the complement process. In the alternate pathways, c3b initiates a positive feedback activation of c3pase. Chemical name: Complement C3b (12 Dec 1998) |
| complement 3b inactivators | Compounds which inhibit, antagonise, or inactivate complement 3b. A well-known inhibitor is a beta-globulin which cleaves c3b into inactive fragments c3c and c3d. C3bina plays a key role in the regulation of the complement system by blocking the cytolytic sequence and preventing recruitment of the properdin amplification loop. (12 Dec 1998) |
| complement 3c | <chemical> An inactivated form of complement 3b (c3b). Complement 3b is inactivated with the help of two regulatory factors, complement factor h and complement factor I. Complement factor h (c3b inactivator accelerator) makes c3b susceptible to the serine protease, complement factor I (formerly called kaf, c3binf, or enzyme 3b inactivator), to form ic3b. Then complement factor I and a trypsin-like proteolytic enzyme further cleave ic3b into c3c and c3dg. Chemical name: Complement C3c (12 Dec 1998) |
| complement 3d | <chemical> An inactivated fragment of complement 3b (c3b). Factor h makes c3b susceptible to factor I (formerly called kaf, c3binf, or enzyme 3b inactivator) to form ic3b. Then factor I and a trypsin-like proteolytic enzyme further cleave ic3b into c3c and c3dg. Serum proteases degrade c3dg into complement 3d (c3d) and c3g. Chemical name: Complement C3d (12 Dec 1998) |
| complement 4 | The second component to react in the complement sequence. It is a beta-globulin with a sedimentation coefficient of 18.7, a molecular weight of 240,000 and a serum concentration of 430 micrograms/ml. It is activated by complement 1 and serves as a receptor for c2. (12 Dec 1998) |
| complement 4a | <chemical> Smaller fragment formed when c1s splits c4 into c4a and c4b. As an anaphylatoxin, c4a causes symptoms of immediate hypersensitivity but it has weaker activity than c3a or c5a. Chemical name: Complement C4a (12 Dec 1998) |
| complement 4b | <chemical> Larger fragment formed when c1s splits c4 into c4a and c4b. C4b combines with c2b to form the activated c4b2b complex which is often called the classical pathway c3 convertase. Chemical name: Complement C4b (12 Dec 1998) |
| complement 5 | The fifth component in the complement reaction sequence, probably exists in a complex with c6 and c7. It is a beta-globulin with a sedimentation coefficient of 10, serum concentration of 75 micrograms/ml and molecular weight of 180,000. It is activated by c423 and releases fragments with anaphylatoxic, chemotactic, and histamine-releasing actions and affecting smooth muscle. (12 Dec 1998) |
| complement 5a | <chemical> Smaller fragment formed when c5 convertase splits c5 into c5a and c5b. C5a is a 74-amino acid peptide that includes a carboxy-terminal arginine crucial for its spasmogenic activity and a carbohydrate moiety. C5a is the most potent anaphylatoxin mediating immediate hypersensitivity. Chemical name: Complement C5a (12 Dec 1998) |
Synonyms : C5a Complement, Complement 5a, Complement Component 5a, 5a, Complement Component, C5a, Complement, Complement, C5a, Component 5a, Complement
Synonyms : C5 a, des-Arg, C5 a, des-Arginine, C5a des-Arg, C5a des-Arginine, C5a, des-Arg, C5a, des-Arginine, Complement 5a, de-Arginine, Complement 5a, des-Arginine, C5 a, des Arg, C5 a, des Arginine, C5a des Arginine, C5a, des Arg, C5a, des Arginine, des-Arg C5 a
Synonyms : C5b Complement, Complement 5b, Complement Component 5b, C5b, Complement, Complement, C5b, Component 5b, Complement
Synonyms : C6 Complement, Complement 6, Complement Component 6, C6, Complement, Complement, C6, Component 6, Complement
Synonyms : C7 Complement, Complement 7, Complement Component 7, C7, Complement, Complement, C7, Component 7, Complement
| combined androgen blockade |
treatment of prostate cancer by blocking both testicular and adrenal androgens, usually through orchiectomy followed by administration of an agent that blocks adrenal androgens.
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| combined aphasia |
aphasia of two or more forms occurring concomitantly in the same person.
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| combustion equivalent |
the heat value of a gram of fat or carbohydrate burned outside the body. It measures the amount of potential energy of the substance available, in the form of food, for the production of heat or the supply of energy.
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| comfortization |
(com
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| Commando's operation |
an operation for management of oral cancer, consisting in resection of the primary lesion and the regional lymphatic nodes.
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| COM | occur |
|---|---|
| COM | gather or bring together |
| COM | gather together over time |
| COM | start running, functioning, or operating, as of lights or power |
| COM | bring forth, usually something desirable |
| COM | move toward, travel toward something or somebody or approach something or somebody |
| COM | move upward |
| COM | come up, of celestial bodies |
| COM | come to the surface |
| COM | get something or somebody for a specific purpose |
| COM | originate or come into being |
| COM | be mentioned |