| immunosuppressed | <immunology> Condition of having a lowered resistance to disease. May be a temporary result of lowered white blood cells from chemotherapy administration. (09 Oct 1997) |
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| immunosuppression | <immunology> This occurs when T and/or B clones of lymphocytes are depleted in size or suppressed in their reactivity, expansion or differentiation. It may arise from activation of specific or non-specific T suppressor lymphocytes of either T or B clones or by drugs that have generalised effects on most or all T or B lymphocytes. Cyclosporin A and FK506 act on T-cells, as does antilymphocyte serum, alkylating agents such as cyclophosphamide are less specific in their action and damage DNA replication, while base analogues interfering with guanine metabolism act in a similar way. See: immunophilin. (18 Nov 1997) |
| immunosuppressive | 1. Denoting or inducing immunosuppression. Synonym: immunosuppressant. (05 Mar 2000) |
| immunosuppressive agent | <immunology, pharmacology> Any chemotherapeutic agent which also has the effect of suppressing the immune system. most often these agents will reduce the absolute number of white blood cells in the bloodstream. (27 Sep 1997) |
| immunosuppressive agents | Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of suppressor T-cell populations or by inhibiting the activation of helper cells. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of interleukins and other cytokines are emerging. (12 Dec 1998) |
| immunosuppressive drugs | Drugs that block the bodys ability to fight infection or foreign substances that enter the body. A person receiving an organ transplant is given these drugs to stop the body from rejecting the new organ or tissue. Cyclosporin is a commonly used immunosuppressive drug. (09 Oct 1997) |
| immunosurveillance | Theory that holds that the immune system eliminates tumour cells that arise spontaneously. (05 Mar 2000) |
| immunosympathectomy | Inhibition of development of sympathetic ganglia induced in newborn animals by injection of antiserum specific for the protein which selectively enhances growth of sympathetic neurons. (05 Mar 2000) |
| immunotherapeutic | <immunology> A therapeutic approach to treat disease by stimulating or enhancing the bodys immune response against the disease. (16 Dec 1997) |
| immunotherapy | <immunology> Treatment of disease by stimulating the bodys own immune system. This is a type of therapy currently being researched as a treatment for cancer. (16 Dec 1997) |
| immunotherapy, active | Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as bcg vaccine and corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system. (12 Dec 1998) |
| immunotherapy, adoptive | Form of adoptive transfer where cells with antitumour activity are transferred to the tumour-bearing host in order to mediate tumour regression. The lymphoid cells commonly used are lymphokine-activated killer (lak) cells and tumour-infiltrating lymphocytes (til). This is usually considered a form of passive immunotherapy. (12 Dec 1998) |
| immunotherapy, allergy | Stimulation of the immune system with gradually increasing doses of the substances to which a person is allergic, the aim being to modify or stop the allergy war (by reducing the strength of the IgE and its effect on the mast cells). This form of treatment is very effective for allergies to pollen, mites, cats, and especially stinging insects (e.g., bees, hornets, yellow jackets, wasps, velvet ants, fire ants). Allergy immunotherapy usually takes 6 months to a year to become effective and shots (injections) are usually required for 3-5 years. (12 Dec 1998) |
| immunotolerance | Lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional. Synonym: immunological tolerance, immunotolerance, nonresponder tolerance. (05 Mar 2000) |
| immunotoxic | <immunology> This refers to any substance which damages the immune system. (09 Oct 1997) |
Synonyms : Adoptive Immunotherapy, Cellular Immunotherapy, Adoptive, Immunotherapy, Adoptive Cellular, Adoptive Cellular Immunotherapies, Adoptive Immunotherapies, Cellular Immunotherapies, Adoptive, Immunotherapies, Adoptive, Immunotherapies, Adoptive Cellular
Synonyms : Affinotoxins, Chimeric Toxin, Immunotoxin, Monoclonal Antibody-Toxin Conjugates, Toxin Carrier, Toxin Conjugate, Antibody Toxin Conjugates, Antibody Toxin Hybrids, Antibody-Toxin Conjugates, Monoclonal, Carrier, Toxin, Carriers, Toxin, Conjugate, Toxin
| immunotherapy |
Treatment aimed at reconstituting an impaired immune system.
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| immunomodulator |
Any substance that influences the immune system. See Interleukins; Immunostimulant; Immunosuppression.
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| immunity |
A natural or acquired resistance to a specific disease. Immunity may be partial or complete, long lasting or temporary.
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| immunization |
Administration of antigenic components of an infectious agent to stimulate a protective immune response.
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| immunocompromised |
Refers to an immune system in which the ability to resist or fight off infections and tumors is subnormal.
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