| fatty infiltration | Abnormal accumulation of fat droplets in the cytoplasm of cells, particularly of fat derived from outside the cells. See: fatty degeneration. (05 Mar 2000) |
|---|---|
| leukaemic infiltration | A pathologic change in leukaemia in which leukaemic cells permeate various organs at any stage of the disease. All types of leukaemia show various degrees of infiltration, depending upon the type of leukaemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukaemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukaemia the skin is often infiltrated. The central nervous system too is a common site. (12 Dec 1998) |
| lipomatous infiltration | Nonencapsulated adipose tissue forming a lipoma-like mass, usually in the cardiac interatrial septum where it may cause arrhythmia and sudden death. Synonym: lipomatous hypertrophy. (05 Mar 2000) |
| antigens, differentiation, b-lymphocyte | Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumours of B-cell origin. (12 Dec 1998) |
| antigens, differentiation, t-lymphocyte | Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function. (12 Dec 1998) |
| bare lymphocyte syndrome | <syndrome> Absence of HLA antigens on peripheral mononuclear cells, which may result in immunodeficiency. (05 Mar 2000) |
| B lymphocyte | <haematology, immunology> An immunologically important lymphocyte, produced by the bone marrow, that is responsible for the production of immunoglobulins, it is the precursor of the plasma cell. The surface markers can be used to detect and differentiate chronic lymphocytic leukaemia from acute lymphocytic leukaemia. (13 Nov 1997) |
| b-lymphocyte subsets | A classification of B-lymphocytes based on structurally or functionally different populations of cells. (12 Dec 1998) |
| gene rearrangement, b-lymphocyte | Ordered rearrangement of b-lymphocyte variable gene regions coding for the immunoglobulin chains, thereby contributing to antibody diversity. It occurs during the differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| gene rearrangement, b-lymphocyte, heavy chain | Ordered rearrangement of b-lymphocyte variable gene regions thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| gene rearrangement, b-lymphocyte, light chain | Ordered rearrangement of b-lymphocyte variable gene regions coding for the kappa or lambda light chains, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the immature b-lymphocyte. (12 Dec 1998) |
| gene rearrangement, t-lymphocyte | Ordered rearrangement of T-cell variable gene regions coding for the antigen receptors. (12 Dec 1998) |
| receptors, lymphocyte homing | Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialised blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes. (12 Dec 1998) |
| virgin lymphocyte | <haematology, immunology> A lymphocyte that has not and whose precursors have not, encountered the antigenic determinant for which it possesses receptors. (18 Nov 1997) |
| CD4 lymphocyte | A specific type of lymphocyte, derived from the thymus gland, that plays an important role in cellular immunity. T4 lymphocytes (CD4 cells) are decreased (absolute counts less than 200) in patients with AIDS resulting in compromised immune function. (27 Sep 1997) |