| substantia nigra | A large cell mass, crescentic on transverse section, extending forward over the dorsal surface of the crus cerebri from the rostral border of the pons into the subthalamic region; it is composed of a dorsal stratum of closely spaced pigmented (i.e., melanin-containing) cells, the pars compacta, and a larger ventral region of widely scattered cells, the pars reticulata; the pars compacta in particular includes numerous cells that project forward to the striatum (caudate nucleus and putamen) and contain dopamine, which acts as the transmitter substance at their synaptic endings; other, apparently non-dopaminergic cells of the substantia nigra project to a rostral part of the ventral nucleus of thalmus, the middle layers of the superior colliculus and to restricted parts of the reticular formation of the midbrain; the nigrostriatal projection is reciprocated by a massive striatonigral fibre system with multiple neurotransmitters, chief among which is gamma-aminobutyric acid (GABA); substantia n. Receives smaller afferent projections from the subthalamic nucleus, the lateral segment of the globus pallidus, the dorsal nucleus of the raphe and the pedunculopontine nucleus of the midbrain. The pars reticulata forms part of the output system for the striate body. The substantia n. Is involved in the metabolic disturbances associated with Parkinson's disease and Huntington's disease. Synonym: locus niger, nucleus niger, Soemmerring's ganglion. (05 Mar 2000) |
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| dermatosis papulosa nigra | Dark brown papular lesions, observed in blacks, on the face and upper trunk; histologically and clinically, they resemble seborrheic keratoses. (05 Mar 2000) |
| tinea nigra | A fungus infection due to Exophiala werneckii, marked by dark lesions giving a spattered appearance and occurring most commonly on the palms of the hands. Synonym: pityriasis nigra. (05 Mar 2000) |
| linea nigra | The linea alba in pregnancy, which then becomes pigmented. Synonym: black line. (05 Mar 2000) |
| lingua nigra | In canines, a disorder associated with a deficency of nicotinic acid. Black to yellowish brown discoloration of the dorsum of the tongue due to staining by exogenous material such as the components of tobacco; usually superimposed on hairy tongue. Synonym: lingua nigra, melanoglossia, nigrities linguae. (05 Mar 2000) |