| trans-Golgi reticulum | That part of the Golgi apparatus that takes newly processed proteins and delivers them to secretory vesicles that will fuse with other biomembranes (e.g., the plasma membrane). (05 Mar 2000) |
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| trans-octaprenyltranstransferase | <enzyme> Level of isopentenyl diphosphate-magnesium(ipp-mg) is decisive in affecting the chain length of the products of prenyltransferase reaction Registry number: EC 2.5.1.11 Synonym: solanesyl diphosphate synthase, solanesyl pyrophosphate synthetase (26 Jun 1999) |
| trans-pentaprenyltranstransferase | <enzyme> From micrococcus luteus b-p26; composed of 2 components; requires all-trans farnesyl or all-trans-geranylgeranyl pyrophosphate Registry number: EC 2.5.1.33 Synonym: all-trans-hexaprenylpyrophosphate synthase, hexaprenyldiphosphate synthetase, trans-pentaprenyltransferase, hexaprenylpyrophosphate synthetase (26 Jun 1999) |
| trans-retinal | The orange retinaldehyde resulting from the action of light on the rhodopsin of the retina, which converts the 11-cis-retinal component of the rhodopsin to all-trans-retinal plus opsin. Synonym: trans-retinal, visual yellow. (05 Mar 2000) |
| trans splicing | <molecular biology> Relating to RNA splicing of two different pre mRNA molecules together. Seems to rely on intron like sequences. Contrasts with the normal cis splicing of conventional RNA molecules. (19 Jan 1998) |
| trans-splicing | Formation of spliced products containing portions of two different transcripts. (05 Mar 2000) |
| accelerated phase of leukaemia | Refers to chronic myelogenous leukaemia that is progressing. The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase, but not as high as in the blast phase. (12 Dec 1998) |
| acceleration phase | <cell biology, cell culture> A period of increasing growth before the log phase in a culture of microbes. After the culture is started on a medium, at first there is no growth (the lag phase) and then the microbes start to gradually grow (acceleration phase) until they reach a constant maximum rate of growth (log phase). (15 Jan 1998) |
| acute-phase protein | <haematology> These plasma proteins (in addition to fibrinogen) increase 25% or more in response to inflammation and injury are under direct control of interleukin-6 (IL-6) (hepatocyte-stimulating factor). Other proteins which increase are ceruloplasmin, C3 and C4 which increase 50% or more; alpha-1 acid glycoprotein, alpha-1 antitrypsin, haptoglobin and fibrinogen (the major determinant of viscosity 1 ) which increase two- to fourfold; C-reactive protein (CRP) and serum amyloid A which increase several hundred-fold. Despite long-held clinical opinion to the contrary, available data indicate that neither ESR nor measurement of specific acute-phase reactants are useful in excluding underlying infection or inflammation regardless of the pretest probability. These proteins are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. They can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumour markers. See also: amyloid, c-reactive protein, erythrocyte sedimentation rate, viscosity. (25 Jun 1999) |
| acute-phase reaction | <immunology, rheumatology> Refers to the changes in synthesis of certain proteins within the serum during an inflammatory response, which provides rapid protection for the host against microorganisms via non-specific defense mechanisms. It consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma; the reaction is mediated by endogenous pyrogens, the hypothalamus, adrenal hormones, and other factors. (12 Jul 2000) |
| anal phase | In psychoanalytic personality theory, the stage of psychosexual development, occurring when a child is between 1 and 3 years, during which activities, interests, and concerns are centreed around the anal zone. (05 Mar 2000) |
| aqueous phase | The water portion of a system consisting of two liquid phase's, one mainly water, the other a liquid immiscible with water (e.g., benzene, ether). (05 Mar 2000) |
| blast phase | Refers to advanced chronic myelogenous leukaemia. In this phase, the number of immature, abnormal white blood cells in the bone marrow and blood is extremely high. Also called blast crisis. (12 Dec 1998) |
| g0 phase | Phase of the cell cycle where cells exist in a quiescent state. These cells have unduplicated DNA, degraded RNA and protein, and low enzyme activity. The ability to switch between g0 and g1 (and vice versa) determines the post-embryonic cell proliferation rate and is defectively controlled in neoplastic cells. (12 Dec 1998) |
| g1 phase | <cell biology, molecular biology> The period during interphase in the cell cycle between mitosis and the S phase (when DNA is replicated). Also known as the decision period of the cell, because the cell decides to divide when it enters the s phase. The G stands for gap. (09 Oct 1997) |