| RTECS | Registry of Toxic Effects of Chemical Substances |
|---|---|
| TRI | tetrazolium reduction inhibition; Thyroid Research Institute; total response index; toxic chemical r... |
| TRIFACTS | Toxic Chemical Release Inventory Facts |
| TS | Takayasu syndrome; Tay-Sachs; temperature sensitivity; temperature, skin; temporal stem; tensile str... |
| COD | 1) Choice Of Drug 2) Cause Of Death 3) Chemical O2 Demand;... |
| negative regulation | Negative feedback in biological systems mediated by allosteric regulatory enzymes. (18 Nov 1997) |
|---|---|
| down-regulation | <physiology> Development of a refractory or tolerant state consequent upon repeated administration of a pharmacologically or physiologically active substance. It is the process that decreases ligand and receptor interactions or reduces the responsiveness of a cell to a stimulus following first exposure. This is often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent reduction in the number of available receptors expressed on the surface which can result from internalisation of the ligand:receptor complex or from decreased expression of the receptor. Classically the concept referred to hormone receptors but contemporary usage includes other cell surface receptors. (03 Jul 1999) |
| target regulation | <physiology> General term for an interaction between neurons and their targets by which target derived signals influence the differentiation of the innervating neurons. (18 Nov 1997) |
| enzyme regulation | <biochemistry> Control of the rate of a reaction catalyzed by an enzyme by some effector (e.g., inhibitors or activators) or by alteration of some condition (e.g., pH or ionic strength). (05 Mar 2000) |
| facility regulation and control | Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer. (12 Dec 1998) |
| feedback regulation | <physiology> Control mechanism that uses the consequences of a process to regulate the rate at which the process occurs: if, for example: the products of a reaction inhibit the reaction from proceeding (or slow down the rate of the reaction), then there is negative feedback, something that is very common in metabolic pathways. Positive feedback is liable to lead to exponential increase and may be explosively dangerous in some cases. Other examples are the action of voltage dependent sodium channels in generating action potentials and the activation of blood clotting factors V and VIII by thrombin. Without damping, feedback can lead to resonance (hunting) and oscillation in the system. (18 Nov 1997) |
| up-regulation | Opposite of down-regulation. (05 Mar 2000) |
| up-regulation (physiology) | Process that increases ligand/receptor interactions due to an increase in the number of available receptors. (12 Dec 1998) |
| megacolon, toxic | Acute dilatation of the colon associated with amebic or ulcerative colitis. The dilatation may precede perforation of the colon. (12 Dec 1998) |
| goiter, diffuse toxic | Graves' disease, the most common cause of hyperthroidism, too much thyroid hormone. (12 Dec 1998) |
| goiter, toxic multinodular | Condition in which the thyroid gland contains multiple lumps (nodules) that are overactive and produce excess thyroid hormones. This condition is also known as Parry's disease or Plummer's disease. (12 Dec 1998) |
| plants, toxic | Plants or plant parts which are harmful to man or other animals. (12 Dec 1998) |
| hepatitis, toxic | Acute hepatitis caused by true hepatotoxins such as amanita phaloides toxin, carbon tetrachloride, yellow phosphorus, and a variety of drugs. (12 Dec 1998) |
| shock, toxic | See Syndrome, toxic shock. (12 Dec 1998) |
| syndrome, toxic shock | A grave condition occurring predominantly in menstruating women using tampons, toxic shock is characterised by a highly toxic state (with sudden high fever, vomiting, diarrhoea, muscle aching) followed by low blood pressure (hypotension) which can lead to shock (and death). There may be a rash resembling sunburn with peeling of skin. The channing laboratory in boston under dr. Edw. Kass discovered that toxic shock was due to a toxin produced by staph (staphylococcus) aureus bacteria growing under conditions with little or no oxygen. The syndrome occurs rarely in women not using tampons and in men. (12 Dec 1998) |