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magnesium protoporphyrin monomethyl ester oxidative cyclase <enzyme> In chlorophyll biosynthesis converts -(ch2)2-coo-ch3 side chain of mg protoporphyrin monomethyl ester to -c=o-ch-cooch3 ring of mg 2,4-divinyl phaeoporphyrin a(5) monomethyl ester; requires NADPH and molecular oxygen; similar to cytochrome p-450 catalyzed systems but not inhibited by co
Registry number: EC 1.14.13.-
Synonym: mpme-oxidative cyclase
(26 Jun 1999)
Gronblad, Ester <person> Swedish ophthalmologist, *1898.
See: Gronblad-Strandberg syndrome.
(05 Mar 2000)
cholesterol ester storage disease A rare benign adult form of inherited lysosomal lipid storage disease that is due to deficiency of acid lipase. It results in an accumulation of neutral lipids, particularly cholesterol esters, within cells (particularly leukocytes, fibroblasts, and liver cells). It is an allelic variant of wolman disease.
(12 Dec 1998)
cholesterol ester transport proteins A protein that transports cholesterol esters from HDL to VLDL and LDL; a deficiency of this protein is associated with elevated HDL cholesterol.
(05 Mar 2000)
cholesteryl ester synthetase <enzyme> Independent of coenzyme a; dependent on bile salts
Registry number: EC 2.3.1.-
(26 Jun 1999)
Robison-Embden ester A key intermediate in glycolysis, glycogenolysis, pentose phosphate shunt, etc.; elevated levels inhibit brain hexokinase and glycolysis.
Synonym: Robison ester, Robison-Embden ester.
(05 Mar 2000)
Robison ester A key intermediate in glycolysis, glycogenolysis, pentose phosphate shunt, etc.; elevated levels inhibit brain hexokinase and glycolysis.
Synonym: Robison ester, Robison-Embden ester.
(05 Mar 2000)
Robison ester dehydrogenase <enzyme> An NADP+ enzyme that catalyses the dehydrogenation (oxidation) of d-glucose-6-phosphate to 6-phospho-d-glucono-d-lactone, this reaction initiating the Dickens shunt.
Deficiency of this enzyme is the commonest disease-causing enzyme defect in humans affecting an estimated 400 million people.
The gene for this enzyme is on the X chromosome. Males with the enzyme deficiency develop haemolytic anaemia when red blood cells are exposed to oxidant drugs such as the antimalarial primaquine, the sulfonamide antibiotics or sulfones, naphthalene moth balls, or fava beans.
Synonym: Robison ester dehydrogenase, Zwischenferment.
Acronym: G6PD
(12 Sep 2002)
cinnamoyl ester hydrolase <enzyme> From butyrivibrio fibrisolvens; genbank u44893
Registry number: EC 3.1.1.-
Synonym: cini gene product, cinb gene product
(26 Jun 1999)
phorbol ester <chemical> Polycyclic compound isolated from croton oil in which two hydroxyl groups on neighbouring carbon atoms are esterified to fatty acids.
The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co carcinogens or tumour promotors, they are diacyl glycerol analogues and activate protein kinase C irreversibly.
(31 Dec 1997)
phthalate ester hydrolase <enzyme> Converts diester into monoester and alcohol
Registry number: EC 3.1.1.-
Synonym: di-n-butyl phthalate hydrolase, di-n-alkyl phthalate hydrolase
(26 Jun 1999)
Cori ester An important intermediate in glycogenesis and glycogenolysis.
Synonym: Cori ester.
(05 Mar 2000)
Harden-Young ester D-fructose 1,6-bisphosphate;important intermediate in sugar metabolism.
(05 Mar 2000)
Neuberg ester <biochemistry> A phosphorylated six-carbon sugar formed in the second step of glycolysis by the action of phosphoglucose isomerase on glucose-6-phosphate. In the third step, fructose 6-phospate and ATP are used to create fructose 1,6-biphosphate, ADP and a free hydrogen with the aid of phosphofructokinase.
(08 Mar 2000)
ng-nitroarginine methyl ester <chemical> A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
Pharmacological action: enzyme inhibitors.
(12 Dec 1998)
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