| CTRS | certified therapeutic recreation specialist |
|---|---|
| DATTA | diagnostic and therapeutic technology assessment |
| DTT | diagnostic and therapeutic team; diphtheria tetanus toxoid; direct transverse traction; dithiothreit... |
| GITS | gastrointestinal therapeutic system |
| HTD | human therapeutic dose |
| therapeutic iridectomy | An iridectomy performed for the prevention or cure of disease, e.g., angle-closure glaucoma. (05 Mar 2000) |
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| therapeutic malaria | Intentionally induced malaria, formerly used against neurosyphilis and certain other paralytic diseases; the mechanism is thought to be immunological, with Plasmodium antibodies cross-reacting against the spirochetes or other agents. (05 Mar 2000) |
| therapeutic pessimism | A disbelief in the curative virtues of remedies in general and especially of drugs. (05 Mar 2000) |
| therapeutic pneumothorax | Pneumothorax designed to create some pulmonary parenchymal collapse, diaphragmatic immobilization, or both. (05 Mar 2000) |
| therapeutic ratio | The ratio of the maximally tolerated dose of a drug to the minimal curative or effective dose; LD50 divided by ED50. (05 Mar 2000) |
| therapeutic touch | The placing of the hands of the healer upon the person to be cured. (12 Dec 1998) |
| therapeutic vaccine | An injected therapy consisting of synthetic HIV antigen (for example, gp160) that is administered to people who already have HIV It is supposed to heighten and broaden the immune response to HIV, helping to halt disease progression. (09 Oct 1997) |
| embolization, therapeutic | A method of haemostasis utilizing various agents such as gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and cerebral arteriovenous malformations, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumours, traumatic rupture of blood vessels, and control of operative haemorrhage. (12 Dec 1998) |
| Bernoulli trial | A single random event for which there are two and only two possible outcomes that are mutually exclusive and have a priori fixed (and complementary) probabilities of resulting. The trial is the realization of this process. Conventionally one outcome is termed a success and is assigned the score 1, the other is a failure and has the score zero. Thus the outcome might be 0 (no heads, one tail) or 1 (1 head, no tails). (05 Mar 2000) |
| randomised controlled trial | A clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Treatment allocations using coin flips, odd-even numbers, patient social security numbers, days of the week, medical record numbers, or other such pseudo- or quasi-random processes, are not truly randomised and a trial employing any of these techniques for patient assignment is designated simply a controlled clinical trial. (12 Dec 1998) |
| randomised trial | <statistics> A clinical trial in which patients have been randomly assigned to receive either the study drug or alternative treatment, in which neither the patient nor the physician conducting the study know which treatment is being given the patient, and in which the alternative to the study drug is a placebo, the study is conducted at several centres. (09 Oct 1997) |
| phase I clinical trial | <pharmacology> The earliest stage clinical trial for studying an experimental drug in humans. Phase I trials are generally comparatively small and are used to determine toxicity and maximum dose. They provide an initial evaluation of a drug's safety and pharmacokinetics-how the drug is absorbed, what tissues it reaches and how long it takes to leave the body. Such studies also usually test various doses of the drug (dose-ranging) to obtain an indication of the appropriate dose to use in later studies. The patients in these trials usually have advanced disease and have already received best available chemotherapy, therefore, seeing a repose is significant partially because this means there is a lack of cross-resistance between two anti-cancer drugs. (31 Dec 1997) |
| phase II clinical trial | <pharmacology> Usually focus on the activity of the new product as a single agent in a noncomparative, open study. (31 Dec 1997) |
| phase III clinical trial | <pharmacology> An advanced stage clinical trial that should conclusively show how well a drug works as compared to other treatments. Phase III trials are large, frequently multi-institution tests. They generally compare the relative value of the new drug compared with the current standard treatment and measure whether a new drug extends survival or otherwise improves the health of patients on treatment (clinical improvement) rather than just provide surrogate marker data. These studies generally last longer and are larger than phase II trials. (31 Dec 1997) |
| clinical trial | <pharmacology> Research study conducted with patients, usually to evaluate a new treatment or drug. Each trial is designed to answer scientific questions and to find better ways to treat individuals with a specific disease. (12 May 1997) |