| systemic mastocytosis | Infiltration of many organ systems by mast cells with varied clinical manifestations that can include fever, weight loss, flushing, bronchospasm, rhinorrhoea, palpitations, dyspnea, diarrhoea, gastrointestinal bleeding, and hypotension. Synonym: systemic mastocytosis. (05 Mar 2000) |
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| systemic myelitis | Inflammation confined to special tracts of the spinal cord. (05 Mar 2000) |
| systemic-onset juvenile chronic arthritis | See: Systemic-onset juvenile rheumatoid arthritis (still's disease). (12 Dec 1998) |
| systemic-onset juvenile rheumatoid arthritis | <rheumatology> A form of joint disease, arthritis, that presents with systemic upset. Clinical signs: high intermittent fever, a salmon-coloured skin rash, swollen lymph glands, enlargement of the liver and spleen, and inflammation of the lungs (pleuritis) and around the heart (pericarditis). The arthritis itself may not be immediately apparent but once apparent, it may persist after the systemic symptoms have resolved. Synonym: Still's disease. (03 Jul 1999) |
| systemic poisoning | Any disease of toxic origin. Synonym: systemic poisoning. Origin: toxico-+ G. -osis, condition (05 Mar 2000) |
| systemic sclerosis | <rheumatology> A multisystem disorder of unknown aetiology. It is characterised by fibrosis (scarring) of the skin, blood vessels and internal organs. Involvement of the gastrointestinal tract, heart, kidneys and lungs is common. (09 Jan 1998) |
| systemic therapy | <pharmacology> Treatment that reaches and affects cells all over the body. (16 Dec 1997) |
| systemic vascular resistance | An index of arteriolar compliance or constriction throughout the body; equal to the blood pressure divided by the cardiac output. (05 Mar 2000) |
| systemic venous hypertension | Increased pressure in the veins ultimately leading to the right atrium nearly always due to disease of the right heart but occasionally due to blockade of one or both venae cavae. (05 Mar 2000) |
| juvenile chronic arthritis, systemic-onset | See: Juvenile rheumatoid arthritis, systemic-onset (still's disease). (12 Dec 1998) |
| juvenile rheumatoid arthritis, systemic-onset | Also known as systemic-onset juvenile chronic arthritis. Still's disease presents with systemic (bodywide) illness including high intermittent fever, a salmon-coloured skin rash, swollen lymph glands, enlargement of the liver and spleen, and inflammation of the lungs (pleuritis) and around the heart (pericarditis). The arthritis may not be immediately apparent but it does always surface and it may persists long after the systemic symptoms are gone. (12 Dec 1998) |
| lupus erythematosus, systemic | A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterised principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown aetiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of le cells in the blood or bone marrow. (12 Dec 1998) |
| air embolism | <physiology> A serious condition that results when air (in the form of bubbles) invades the blood vessels causing disruption of normal blood flow. (06 Aug 1998) |
| amniotic fluid embolism | Obstruction and constriction of pulmonary blood vessels by amniotic fluid entering the maternal circulation, causing obstetric shock. See: amniotic fluid syndrome. (05 Mar 2000) |
| arterial embolism | <cardiology, physiology> A sudden interruption in arterial blood flow to an organ or body part (extremity). The blockage is caused by a blot clot or atherosclerotic plaque that has moved through the arterial circulation from one position to another. The resulting mechanism is the same regardless of cause or location. Oxygen deprivation to the tissues distal to the occlusion become ischaemic and die (necrosis). Atrial fibrillation is a risk factor for arterial embolism due to the release of blood clots from the fibrillating heart. Blood vessel injury and increased levels of platelets can also be a risk for arterial embolism. Symptoms vary with location, but pain, coolness to an extremity and a absent or diminished pulse are common in the case of an extremity embolism. Treatment is often surgical or involves the use of blood clot dissolving medications (for example streptokinase) delivered selectively to the site of the blockage. (17 Oct 1997) |