| LPF | leukocytosis-promoting factor; leukopenia factor; lipopolysaccharide factor; localized plaque format... |
|---|---|
| PFC | pair-fed control [mice]; patient-focused care; pelvic flexion contracture; perfluorocarbon; pericard... |
| PFU | plaque-forming unit; pock-forming unit |
| PI | first meiotic prophase; isoelectric point; pacing impulse; package insert; pancreatic insufficiency;... |
| PN | papillary necrosis; parenteral nutrition; penicillin; perceived noise; percussion note; periarteriti... |
| pleural plaque | Fibrous thickening of the parietal pleura, characteristically caused by inhalation exposure to asbestos. (05 Mar 2000) |
|---|---|
| haemolytic plaque assay | <investigation> A haemolytic plaque assay is a lab technique used to show that certain antibodies are secreted by antibody-making cells when these cells are mixed with red blood cells. The mixture is spread onto a plate of agar, if a plaque appears, it means that the red blood cells have been destroyed (by haemolysis) by the antibodies. (09 Oct 1997) |
| senile plaque | <neurology> Characteristic feature of the brains of Alzheimer's patients and aged monkeys, consisting of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of amyloid fibrils in senile plaques is B/A4, a peptide of about 4 kD that is derived from the larger amyloid precursor protein (APP). The B/A4 sequence is located near the C terminus of APP. (18 Nov 1997) |
| neuritic plaque | <cell biology> Abnormal cluster of dead and dying nerve cells, other brain cells and protein. Neuritic plaques are one of the characteristic structural abnormalities found in the brains of alzheimer patients. Upon autopsy, the presence of neuritic plaques andneurofibrillary tangles is used to positively diagnose Alzheimer's disease. (22 May 1997) |
| dental plaque | <dentistry> A soft, thin film of food debris, mucin and dead epithelial cells deposited on the teeth, providing the medium for the growth of various bacteria. The main inorganic components are calcium and phosphorus with small amounts of magnesium, potassium and sodium, the organic matrix consists of polysaccharides, proteins, carbohydrates, lipids and other components. Plaque plays an important aetiological role in the development of dental caries and periodontal and gingival diseases and provides the base for the development of materia alba, calcified plaque forms dental calculus. (19 Mar 1998) |
| dental plaque index | An index which scores the degree of dental plaque accumulation. (12 Dec 1998) |
| fibrous plaque | Thickened area of arterial intima with accumulation of smooth muscle cells and fibrous tissue (collagen etc.) produced by the fat laden smooth muscle cells. Below the thickening may be free extracellular lipid and debris that, if much necrosis is also present, is referred to as an atheroma. (18 Nov 1997) |
| bilaterally small, smooth kidneys | <radiology> Generalised atherosclerosis, nephrosclerosis - benign and malignant, atheroembolic renal disease, chronic glomerulonephritis, papillary necrosis, hereditary diseases, hereditary chronic nephritis (Alport's syndrome), medullary cystic disease, amyloidosis (late), arterial hypotension Cf: other urographic patterns (12 Dec 1998) |
| carcinoma, non-small-cell lung | A heterogeneous aggregate of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. They are dealt with collectively because of the shared properties of poor response to conventional chemotherapy and the potential for cure with surgical resection in a fraction of patients. (12 Dec 1998) |
| carcinoma, small cell | An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterised by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. There are admixtures of small cell lung carcinoma with other types of lung cancer. Small cell carcinomas are distinguished by their distinctive biological features, response to chemotherapy and radiotherapy, and by their nearly universal tendency to develop overt or subclinical metastases, which frequently eliminates surgery in most patients. (12 Dec 1998) |
| generalised small bowel disease | <radiology> Hypoproteinaemia, sprue, Whipple (12 Dec 1998) |
| mesenteric portion of small intestine | The freely movable portion of the small intestine supplied with a mesentery, comprising the jejunum and ileum. Synonym: mesenteric portion of small intestine. (05 Mar 2000) |
| ribonucleoproteins, small nuclear | Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm. The u3 snrnp is localised in the nucleolus, where it aligns into base pairs with the 28s rrna precursor in a still unidentified region and functions in pre-rrna processing. The u7 snrnp aligns into base pairs with a conserved sequence in the 3'-end of histone pre-mRNA and is an essential cofactor for the cleavage that creates the mature nonadenylated 3'-end. (12 Dec 1998) |
| ribonucleoproteins, small, u1 | A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the u1 snrnp along with other small ribonucleoproteins (u2, u4-u6, and u5) assemble into spliceosomes that remove introns from pre-mRNA by splicing. The u1 snrnp base pairs with conserved sequence motifs at the 5'-splice site and recognises both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction. (12 Dec 1998) |
| ribonucleoproteins, small, u2 | A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the u2 snrnp along with other small ribonucleoproteins (u1, u4-u6, and u5) assemble into spliceosomes that remove introns from pre-mRNA by splicing. The u2 snrnp base pairs with conserved sequence motifs at the branch point, which associates with a heat- and rnaase-sensitive factor in an early step of splicing. (12 Dec 1998) |