| CFU-S, | CFUS colony-forming unit, spleen; colony-forming unit, stem cells |
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| SC | conditioned stimulus; sacrococcygeal; Sanitary Corps; scalenus [muscle]; scapula; Schwann cell; scia... |
| SB | Bachelor of Science; Schwartz-Bartter [syndrome]; serum bilirubin; shortness of breath; sick bay; si... |
| SCA | self-care agency; severe congenital anomaly; sickle-cell anemia; single-camera autostereoscopic [ima... |
| SPC | salicylamide, phenacetin, and caffeine; seropositive carrier; single palmar crease; single photoelec... |
| colony count, microbial | Enumeration by direct count of viable, isolated bacterial or fungal cells or spores capable of growth on solid culture media. Each colony (i.e., microbial colony-forming unit) represents the progeny of a single cell in the original inoculum. The method is used routinely by environmental microbiologists for quantifying organisms in air, food, and water; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing. (12 Dec 1998) |
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| colony-forming unit | <cell biology> An individual cell which is able to clone itself into an entire colony of identical cells. Irradiated mice can have their immune systems reconstituted by the injection of bone marrow cells from a nonirradiated animal. The injected cells form colonies in the spleen (hence s), each colony representing the progeny of a pluripotent stem cell. Operationally, therefore, the number of colony-forming units is a measure of the number of stem cells. Acronym: CFU (09 Oct 1997) |
| colony-forming units assay | A cytologic technique for measuring the functional capacity of stem cells by assaying their activity. (12 Dec 1998) |
| colony hybridisation | <molecular biology> A genetics lab technique used to identify which colonies of bacteria on an agar plate contain a particular sequence of DNA or a particular gene. The technique involves pressing a nylon or nitrocellulose membrane onto the plate so that each colony contributes a small smudge of itself to the membrane, then treating the membrane with chemicals and heat, then washing the membrane with a labelled probe to find the specific DNA sequence. The smudges which are indicated by the probe are then compared back to the colonies on the agar plate. This technique is often used in conjunction with experiments involving the making of genomic libraries. (09 Oct 1997) |
| colony-stimulating factor | <cell biology> A glycoprotein growth factor that regulates the differentiation of particular cells. These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically and can exert actions on several lines of progenitor cells, and influence end cell function. These lymphokines induce the maturation and proliferation of white blood cells from the primitive cell types present in bone marrow such as the leucocyte, macrophage and monocyte lines. These substances can also be made by recombinant DNA technology for use clinically to speed bone marrow recovery typically following chemotherapy. Acronym: CSF (18 Jul 2002) |
| mother colony | A colony which gives rise to a secondary colony (a daughter colony), the latter growing on the surface of the former; the mother colony is larger than the daughter colony, and the characteristics of the colony's may differ. (05 Mar 2000) |
| mucoid colony | A colony showing viscous or sticky growth typical of an organism producing large quantities of a carbohydrate capsule. (05 Mar 2000) |
| multi-colony-stimulating factor | <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells. A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors. Synonym: multi-CSF Acronym: IL-3 (12 Dec 1998) |
| multipotential colony-stimulating factor | <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells. A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors. Synonym: multi-CSF Acronym: IL-3 (12 Dec 1998) |
| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
| H colony | <cell culture> A colony of motile organisms forming a thin film of growth. Compare: O colony. Origin: Ger. Hauch, breath (05 Mar 2000) |
| single | 1. One only, as distinguished from more than one; consisting of one alone; individual; separate; as, a single star. "No single man is born with a right of controlling the opinions of all the rest." (Pope) 2. Alone; having no companion. "Who single hast maintained, Against revolted multitudes, the cause Of truth." (Milton) 3. Hence, unmarried; as, a single man or woman. "Grows, lives, and dies in single blessedness." (Shak) "Single chose to live, and shunned to wed." (Dryden) 4. Not doubled, twisted together, or combined with others; as, a single thread; a single strand of a rope. 5. Performed by one person, or one on each side; as, a single combat. "These shifts refuted, answer thy appellant, . . . Who now defles thee thrice ti single fight." (Milton) 6. Uncompounded; pure; unmixed. "Simple ideas are opposed to complex, and single to compound." (I. Watts) 7. Not deceitful or artful; honest; sincere. "I speak it with a single heart." (Shak) 8. Simple; not wise; weak; silly. "He utters such single matter in so infantly a voice." (Beau & Fl) Single ale, beer, or drink, small ale, etc, as contrasted with double ale, etc, which is stronger. Single bill, a single rope running through a fixed block. Origin: L. Singulus, a dim. From the root in simplex simple; cf. OE. & OF. Sengle, fr. L. Singulus. See Simple, and cf. Singular. 1. To select, as an individual person or thing, from among a number; to choose out from others; to separate. "Dogs who hereby can single out their master in the dark." (Bacon) "His blood! she faintly screamed her mind Still singling one from all mankind." (More) 2. To sequester; to withdraw; to retire. "An agent singling itself from consorts." (Hooker) 3. To take alone, or one by one. "Men . . . Commendable when they are singled." (Hooker) Origin: Singled; Singling. Source: Websters Dictionary (01 Mar 1998) |
| single ascertainment | Method of ascertainment of locating affected individuals by hospital or clinic admission or another way in which probability of encountering the same family twice approaches zero; thus, the probability that a family will be ascertained is proportional to the number of affected members. (05 Mar 2000) |
| single-blind method | A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned. (12 Dec 1998) |
| single bond | A covalent bond resulting from the sharing of one pair of electrons; e.g., H3C-CH3 (ethane). (05 Mar 2000) |