| Bochdalek's gap | A triangular area in the diaphragm near the lateral arcuate ligament that is devoid of muscle fibres; it is covered by pleura superiorly and by peritoneum inferiorly. Synonym: Bochdalek's gap, trigonum lumbocostale. (05 Mar 2000) |
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| gap | A space in between two of the same objects, where part of a chain or object is missing, or where certain activities, processes, or events are lacking. A period of time characterised by a lack of activity, in between two events or within a continuous process. <genetics, molecular biology> A gap is a spot on a strand of DNA or RNA where a nucleotide or a segment of nucleotides is missing. (09 Oct 1997) |
| gap 1 | In the somatic cell cycle, the gap that follows mitosis and is followed by synthesis in preparation for the next cycle. (05 Mar 2000) |
| GAP-1 receptor tyrosine kinase | <enzyme> Similar to rasGTPase-activating proteins; inhibits signaling activity of let-60; amino acid sequence given in first source Registry number: EC 2.7.1.- Synonym: gap-1 gene product, gap-1 protein (26 Jun 1999) |
| gap 2 | In the somatic cell cycle, a pause between completion of synthesis and the onset of cell division. (05 Mar 2000) |
| gap-43 protein | A nervous tissue specific protein which is highly expressed in neurons during development and nerve regeneration. It has been implicated in neurite outgrowth, long-term potentiation, signal transduction, and neurotransmitter release. It is also a substrate of protein kinase c. (12 Dec 1998) |
| gap arthroplasty | The surgical correction of ankylosis by creating a space between the ankylosed part of a joint and the portion for which movement is desired. (05 Mar 2000) |
| gap gene | <molecular biology> Segmentation genes involved in specifying relatively coarse subdivisions of the embryo. They are expressed sequentially in development between egg polarity genes and pair rule genes. In Drosophila, there are at least three such genes, for example Kruppel. (18 Nov 1997) |
| gap junction | <cell biology> A junction between two cells consisting of many pores that allow the passage of molecules up to about 900D. Each pore is formed by an hexagonal array (connexon) of six transmembrane proteins (connexins) in each plasma membrane: when mated together the pores open, allowing communication and the interchange of metabolites between cells. Electrical synapses are gap junctions and metabolic cooperation depends upon the formation of gap junctions. (18 Nov 1997) |
| gap junctions | Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junctions. (12 Dec 1998) |
| gap mutant | <molecular biology> A fruit fly of the genus Drosophila which is missing a number of adjacent segments because the segments failed to develop. (09 Oct 1997) |
| gap phenomenon | A short period in the cycle of the atrioventricular or intraventricular conduction allowing passage of an impulse which at other times would be blocked in transit. Synonym: excitable gap. (05 Mar 2000) |
| GAP protein | <molecular biology> Originally purified as a 125 kD protein from bovine brain (1044 amino acids), stimulates the GTPase activity of ras p21 and thereby switches it to the inactive state. GAP may itself be regulated by phospholipids and by phosphorylation on a tyrosine residue by growth factor receptors (PDGF R, EGF R). The neurofibromatosis type 1 gene NF1) codes for a protein homologous to GAP. GAP has both SH2 and SH3 domains. Another example is sar 1 (from yeast). (18 Nov 1997) |
| chromosomal gap | A localised area of thinning in a chromatid which may simulate a complete break. (05 Mar 2000) |
| DNA gap | A localised loss of one of the two strands in the double helix of DNA. (05 Mar 2000) |