| seronegative s's |
a general term comprising a number of degenerative joint diseases having common clinical, immunologic, pathologic, and radiographic features, including synovitis of the peripheral joints, enthesopathy, bony ankylosis of the large peripheral joints, lack of rheumatoid factor, and, in many cases, a positive status for the human leukocyte antigen HLA-B27. Included in this group are enteropathic arthritis, psoriatic arthritis, ankylosing spondylitis, and Reiter's syndrome.
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