| juvenile rheumatoid arthritis | <pathology> Juvenile rheumatoid arthritis (JRA) is a form of rheumatoid arthritis in children that generally occurs prior to age 16. In contrast with the adult type, a fever is more pronounced. Cardiac involvement with pericarditis is more common. The arthritis favors one or more large joints and can interfere with normal bone growth. A positive rheumatoid factor is seen more uncommonly in this form of arthritis. Treatment is similar to the adult form of the disease. Up to 75% recover with treatment. Less than 10% are severely disabled by JRA. (27 Sep 1997) |
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| juvenile rheumatoid arthritis, systemic-onset | Also known as systemic-onset juvenile chronic arthritis. Still's disease presents with systemic (bodywide) illness including high intermittent fever, a salmon-coloured skin rash, swollen lymph glands, enlargement of the liver and spleen, and inflammation of the lungs (pleuritis) and around the heart (pericarditis). The arthritis may not be immediately apparent but it does always surface and it may persists long after the systemic symptoms are gone. (12 Dec 1998) |
| factor, rheumatoid | Rheumatoid factor is an antibody that is measurable in the blood. It is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with rheumatoid arthritis. It is also present in patients with other connective tissue diseases (such as systemic lupus erythematosus) and in some with infectious diseases (such as infectious hepatitis). (12 Dec 1998) |
| aggregated lymphatic nodules | Lymphoid organs located in the sub mucosal tissue of the mammalian gut containing very high proportions of IgA secreting precursor cells. The patches have B and T dependent regions and germinal centres. A specialised epithelium lies between the patch and the intestine. Involved in gut associated immunity. (18 Nov 1997) |
| Albini's nodules | Minute fibrous nodule's on the margins of the mitral and tricuspid valves of the heart, sometimes present in the neonate and representing foetal tissue rests; described previously by Cruveilhier. Compare: nodule of semilunar valve. (05 Mar 2000) |
| apple jelly nodules | Descriptive term for the papular lesions of lupus vulgaris, as they appear on diascopy. (05 Mar 2000) |
| Aschoff nodules | <pathology> Small granulomas composed of macrophages, lymphocytes and multinucleate cells grouped around eosinophilic hyaline material derived from collagen. Characteristic of the myocarditis of rheumatic fever. (18 Nov 1997) |
| Bohn's nodules | Tiny multiple cysts in newborns. They are found at the junction of the hard and soft palates and along buccal and lingual parts of the dental ridges and are derived from epithelial remnants of mucous gland tissue. (05 Mar 2000) |
| Caplan's nodules | <syndrome> Pneumoconiosis associated with rheumatoid arthritis. (12 Dec 1998) |
| Gamna-Gandy nodules | Small firm spheroidal or irregular foci that are yellow-brown, brown, or rustlike in colour, occurring chiefly in the spleen in such conditions as congestive splenomegaly and sickle cell disease, and consisting of relatively dense fibrous tissue or collagenous fibres impregnated with iron pigment and calcium salts; probably result from organization and scarring of sites where small perivascular haemorrhages occurred. Synonym: Gamna-Gandy nodules, Gandy-Gamna bodies, siderotic nodules. (05 Mar 2000) |
| malpighian nodules | Small nodular masses of lymphoid tissue attached to the sides of the smaller arterial branches. Synonym: folliculi lymphatici lienales, malpighian bodies, malpighian corpuscles, malpighian glands, malpighian nodules, splenic corpuscles, splenic lymph nodules. (05 Mar 2000) |
| cavitary lung nodules | <radiology> TB, fungal infection (including Coccidioides), septic pulmonary emboli, metastases, necrobiotic rheumatoid nodules, Wegener's granulomatosis (12 Dec 1998) |
| vocal cord nodules | Small, circumscribed, bilateral, beadlike enlargements on the vocal cords caused by overuse or abuse of the voice; often reversible by voice therapy. Synonym: singer's nodes, singer's nodules, teachers' nodes. (05 Mar 2000) |
| milkers' nodules | An infection of cows' udders by pseudocowpox virus, a member of the Poxviridae, that is transmitted to the fingers and hands of milkers, producing nodules and lymphangitis, and occasionally widespread papular or papulovesicular eruptions; human infection is transferable to uninfected cows. Synonym: milkers' nodes, paravaccinia, pseudocowpox. (05 Mar 2000) |
| picker's nodules | Lichenified skin nodules seen in prurigo nodularis. (05 Mar 2000) |