| pyrroline carboxylate reductases | <enzyme> A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(p)h. Includes both the 2-oxidoreductase (ec 1.5.1.1) and the 5-oxidoreductase (ec 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline. Registry number: EC 1.5.1.- (12 Dec 1998) |
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| pyrroline-2-carboxylate reductase | An oxidoreductase reducing 1-pyrroline-2-carboxylate to l-proline with NAD(P)H. Synonym: proline dehydrogenase, proline oxidase. (05 Mar 2000) |
| pyrroline-5-carboxylate reductase | An oxidoreductase reversibly reducing 1-pyrroline-5-carboxylate to l-proline with NAD(P)H; a deficiency of this enzyme is associated with type I hyperprolinaemia. Synonym: proline dehydrogenase, proline oxidase. (05 Mar 2000) |
| pyrrolizidine alkaloids | <chemical> Alkaloids found in various species of senecio and other plants. There are at least ten different chemicals, many of them hepatotoxic, teratogenic, and carcinogenic. The plants may cause damage in grazing herds, but no longer have medical use. Pharmacological action: carcinogens. (12 Dec 1998) |
| pyrrolnitrin | <chemical> 3-chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from pseudomonas pyrrocinia. It is effective mainly against trichophyton, microsporium, epidermophyton, and penicillium. Pharmacological action: antibiotics, antifungal. Chemical name: 1H-Pyrrole, 3-chloro-4-(3-chloro-2-nitrophenyl)- (12 Dec 1998) |
Synonyms : Alkaloids, Pyrrolizidine, Alkaloids, Senecio
Synonyms :
Synonyms : Pyrrolo-Iminoquinones, Pyrrolo Iminoquinones
| pyrroline 5-carboxylate synthase |
a mitochondrial enzyme activity that catalyzes the conversion of glutamate to Δ1-pyrroline 5-carboxylate, an intermediate in the synthesis of proline. ATP is hydrolyzed in the reaction and NADPH is the electron donor.
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| pyrroline-5-carboxylate reductase |
[EC 1.5.1.2] an enzyme of the oxidoreductase class that catalyzes the irreversible reduction of Δ1-pyrroline 5-carboxylate to proline, using NADPH (or NADH) as an electron donor; the reaction is the final step in the biosynthesis of proline from glutamate or ornithine. The enzyme may also reduce the 3-hydroxy analog of pyrroline 5-carboxylate to form hydroxyproline.
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| pyrroloporphyria |
acute intermittent porphyria.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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