| PFKP | phosphofructokinase, platelet type; 6-phosphofructo-2-kinase, platelet type |
|---|---|
| PM | after death (Lat. post mortem); after noon [Lat. post meridiem]; mean pressure; pacemaker; pantomogr... |
| IHA test | Indirect Hem-Agglutination test |
| LA | 1) Left Atrium 2) Latex Agglutination |
| TGHA | Thyro-Globulin Hem-Agglutination |
| immune agglutination | Agglutination caused by antibody (agglutinin) that is specific for the suspended microorganism, cell, or for an antigen that has been coated on a particle of suitable size. (05 Mar 2000) |
|---|---|
| indirect agglutination | Agglutination of particles that have been coated with soluble antigen, by antiserum specific for the adsorbed antigen. Synonym: indirect agglutination. (05 Mar 2000) |
| false agglutination | 1. Agglomeration of particles in solution which does not involve antigen-antibody combination. Synonym: false agglutination. Synonym: rouleaux formation. (05 Mar 2000) |
| latex agglutination | Also known as latex particle agglutination, for detection of antibodies is identical to haemagglutination in principle, but the substitution of smaller, antigen-coated latex particles for erythrocytes results in improved sensitivity and reagent longevity. Alternatively, antibodies can be absorbed to the latex particles (under appropriate ionic and pH conditions) by binding to the Fc region of antibodies, leaving the Fab region free to interact with antigens present in the applied specimens. This phenomenon has made latex agglutination a popular technique for detecting antigens as well. (05 Mar 2000) |
| latex agglutination test | A passive agglutination test in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. Synonym: latex fixation test. (05 Mar 2000) |
| acquired platelet function defect | <haematology> Platelet function can be affected by a number of different disease processes including polycythaemia vera, leukaemia, myelofibrosis, renal failure, multiple myeloma and some medications (for example penicillins, salicylates, phenothiazines). Disturbed blood clotting can be manifested by: easy bruising, bleeding gums, nosebleeds, abnormal vaginal bleeding, rectal bleeding, skin rash, vomiting blood, coughing up blood or blood in the urine. A measure of bleeding time and coagulation profile will be part of the evaluation. (29 Dec 1997) |
| antigens, human platelet | Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy. (12 Dec 1998) |
| anti-platelet agents | Medications that, like aspirin, reduce the tendency of platelets in the blood to clump and clot. (12 Dec 1998) |
| receptors, platelet-derived growth factor | Specific molecular sites or structures on cell membranes that react with platelet-derived growth factor, its analogs, or antagonists, to elicit or to inhibit the specific response of the cell to this factor. Pdgf binds with different affinities and specificities to two structurally related receptors, the alpha-receptor and the beta-receptor. Both of these receptors are transmembrane proteins with an intracellular, ligand-stimulatable protein kinase domain. (12 Dec 1998) |
| medication, anti-platelet | Platelet-blocking drugs. Drugs that, like aspirin, reduce the tendency of platelets in the blood to clump and clot. (12 Dec 1998) |
| platelet | <haematology> A discoid cell (3m diameter) found in large numbers in blood, important for blood coagulation and for haemostasis by repairing breaches (small breaks) in the walls of blood vessels. Platelet _ granules contain lysosomal enzymes, dense granules contain ADP (a potent platelet aggregating factor) and serotonin (a vasoactive amine). They also release platelet-derived growth factor which presumably contributes to later repair processes by stimulating fibroblast proliferation. Synonym: thrombocytes. (09 Oct 1997) |
| platelet-activating factor | <cytokine> Potent phospholipid activator and mediator of many leucocyte functions, including platelet aggregation, inflammation, and anaphylaxis. It is produced in response to specific stimuli by a variety of cell types, including neutrophils, basophils, platelets, and endothelial cells. Several molecular species of platelet-activating factor have been identified which vary in the length of the O-alkyl side chain. It is an important mediator of bronchoconstriction. Synonym: platelet-aggregating factor. Acronym: PAF (20 Sep 2002) |
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable haemostatic plug. (12 Dec 1998) |
| platelet actomyosin | The contractile protein of platelets, responsible for clot retraction, platelet aggregation, and release of ADP and other biologic amines essential to platelet function. Synonym: thrombosthenin. (05 Mar 2000) |
| platelet adhesiveness | The process whereby platelets adhere to something other than platelets, e.g., collagen, basement membranes, microfibrils, or other "foreign" surfaces. (12 Dec 1998) |