| plasminogen activator i. |
any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. The concentration in plasma of the inhibitors is normally low, but is altered in some disturbances of the hemostatic system. PAI-1 is an important fast-reacting inhibitor of t-PA and u-PA. Its synthesis, activity, and release are highly regulated. Elevated levels of the inhibitor have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
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