| thiazole-4-carboxamide-adenine dinucleotide phosphodiesterase | <enzyme> Hydrolyzes thiazole-4-carboxamide adenine dinucleotide, releasing AMP Registry number: EC 3.1.4.- Synonym: tad-phosphodiesterase (26 Jun 1999) |
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| 2',3'-cyclic nucleotide 2'-phosphodiesterase | <enzyme> Catalyses the hydrolysis of the 2'-phosphodiesterase bond to yield nucleoside 3'phosphate Registry number: EC 3.1.4.16 Synonym: 2',3'-cyclic nucleotide 2'-phosphohydrolase (26 Jun 1999) |
| 2',3'-cyclic nucleotide 3'-phosphodiesterase | <enzyme> Catalyses the hydrolysis of the 3'-phosphoesterase bond to yield nucleoside 2'-phosphate Registry number: EC 3.1.4.37 Synonym: 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cn phosphodiesterase, 2',3'-cnpase (26 Jun 1999) |
| 3',5'-cyclic-GMP phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate. Chemical name: 3',5'-Cyclic-GMP 5'-nucleotidohydrolase Registry number: EC 3.1.4.35 (12 Dec 1998) |
| 3',5'-cyclic-nucleotide phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of cyclic AMP to form adenosine 5'-phosphate. The enzyme is widely distributed in animal tissue and controls the level of intracellular cyclic AMP. Also acts on 3',5'-cyclic imp and 3',5'-cyclic GMP. Chemical name: 3',5'-Cyclic-nucleotide 5'-nucleotidohydrolase Registry number: EC 3.1.4.17 (12 Dec 1998) |
| 4-nitrophenylphosphorylcholine phosphodiesterase | <enzyme> Catalyses the conversion of p-nitrophenylphosphocholine to yield p-nitrophenol and choline phosphate; may be the same as EC 3.1.4.38, glycerophosphocholine cholinephosphodiesterase Registry number: EC 3.1.4.- Synonym: pnp phosphocholine phosphodiesterase, pnppc phosphodiesterase, p-nitrophenylphosphorylcholine phosphodiesterase (26 Jun 1999) |
| adrenergic uptake inhibitors | Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (antidepressive agents, tricyclic) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (12 Dec 1998) |
| blood coagulation factor inhibitors | Substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria. (12 Dec 1998) |
| Bowman Birk protease inhibitors | <pharmacology> Family of serine protease inhibitors found in seeds of leguminous plants and cereals. (18 Nov 1997) |
| carbonic anhydrase inhibitors | A class of compounds that reduces the secretion of h+ ions by the proximal kidney tubule through inhibition of carbonic anhydrase (carbonate dehydratase). Although their therapeutic use as diuretics is not frequent, they are used in clinical conditions where alkalinization of the urine is beneficial. Their most frequent application is in the reduction of intra-ocular pressure in the treatment of glaucoma. (12 Dec 1998) |
| reverse transcriptase inhibitors | Inhibitors of reverse transcriptase (RNA-directed DNA polymerase), an enzyme that synthesises DNA on an RNA template. (12 Dec 1998) |
| growth inhibitors | Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= plant growth regulators). (12 Dec 1998) |
| monoamine oxidase inhibitors | A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. Although mao inhibitors are probably as effective as tricyclic antidepressants in the treatment of major depression, the complex, sometimes severe, and often unpredictable interactions between mao inhibitors and many other drugs and food-derived amines make their medical use difficult and potentially hazardous. (12 Dec 1998) |
| platelet aggregation inhibitors | Drugs or agents which antagonise or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (12 Dec 1998) |
| cysteine proteinase inhibitors | Exogenous and endogenous compounds which inhibit cysteine proteinases. (12 Dec 1998) |