| phage integrase family | <enzyme> Enzymes that mediate site specific recombination in prokaryotes. They fall into two families, phage integrases and resolvases. (18 Nov 1997) |
|---|---|
| phage typing | <microbiology> Bacteria may be typed by their susceptibility to a range of bacteriophages though confusion may arise if the bacteria carry plasmids encoding restriction endonucleases. (18 Nov 1997) |
| mitochondrial genome | All of the DNA in the mitochondrial chromosome. (12 Dec 1998) |
| helper phage | A virus which helps a separate and unrelated defective virus reproduce by infecting the same host cell that is already occupied by the defective virus and providing the proteins which the defective virus is missing and needs to complete its life cycle. (09 Oct 1997) |
| human genome | The full collection of genes in a human being. (12 Dec 1998) |
| human genome initiative | <molecular biology> Collective name for several projects begun in 1986 by the Department of Energy to create an ordered set of DNA segments from known chromosomal locations, develop new computational methods for analysing genetic map and DNA sequence data, and develop new techniques and instruments for detecting and analysing DNA. This initiative is now known as the Human Genome Program. The national effort, led by DOE and National Institute of Health, is known as the Human Genome Project. (09 Oct 1997) |
| human genome project | <molecular biology> A worldwide project to determine the DNA sequence of all the DNA in humans, funded primarily by the U.S. Department of Energy (DOE), the U.S. National Institutes of Health (NIH), the European Commission (EC), and the pharmaceutical and biotechnology industries. The project will be completed in stages, beginning with a genetic map of man and a sequencing of all human cDNA. As part of the Human Genome Project, the genomes of several other plant and animal models are being studied. (14 Nov 1997) |
| ssDNA phage | <molecular biology> Single strand DNA phages such as MS2, FX174, as opposed to double stranded DNA phages or RNA phages. (10 Mar 1998) |
| defective phage | A temperate bacteriophage mutant whose genome does not contain all of the normal components and cannot become fully infectious virus, yet can replicate indefinitely in the bacterial genome as defective probacteriophage; many defective bacteriophage's are mediators of transduction. Synonym: defective phage. (05 Mar 2000) |
| q beta phage | <molecular biology> A single-stranded RNA phage that specifically infects enterobacteria containing the f plasmid. It is widely used to study RNA phage and bacterial cell function. (10 Oct 1997) |
| tailed phage | A member of a group of hundreds of DNA-based bacteria-infecting viruses which are characterised by a helix-shaped tail and a cube-shaped head.This group includes the viral families Myoviridae, Podoviridae, andSiphoviridae. (09 Oct 1997) |
| temperate phage | A bacteriophage that integrates its DNA into that of the host (lysogeny) as opposed to virulent phages that lyse the host. (18 Nov 1997) |
| T even phage | <microbiology> A group of dsDNA bacteriophages of enterobacteria including T2, T4, T6 as opposed to T odd phage (T1, 3, 5 and 7) (18 Nov 1997) |
| lambda phage | <virology> Bacterial DNA virus, first isolated from E. Coli. Its structure is similar to that of the T even phages. Lambda genetic material consists of a double-stranded DNA molecule with 5' twelve-base-pair sticky ends, known as cos sites, which permit circularisation of the DNA molecule. It shows a lytic cycle and a lysogenic cycle and studies on the control of these alternative cycles have been very important for our understanding of the regulation of gene transcription. It is used as a cloning vector, accommodating fragments of DNA up to 15 kilobase pairs long. For larger pieces, the cosmid vector was constructed from its ends. (14 Mar 2000) |
| lytic phage | A bacteriophage (virus which infects bacteria) that can only follow the lytic pathway to completing its lytic cycle, and does not have the mechanisms to enter the lysogenic pathway. (09 Oct 1997) |