| oncogene proteins v-fos | Transforming proteins coded by fos oncogenes. These proteins have been found in the finkel-biskis-jinkins (fbj-msv) and finkel-biskis-reilly (fbr-msv) murine sarcoma viruses which induce osteogenic sarcomas in mice. The fbj-msv v-fos gene encodes a p55 kD protein and the fbr-msv v-fos gene encodes a p75 kD fusion protein. (12 Dec 1998) |
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| oncogene proteins, viral | Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities. (12 Dec 1998) |
| oncogene proteins v-mos | Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the moloney murine sarcoma virus (mo-msv). (12 Dec 1998) |
| recombinant fusion proteins | Proteins that are the result of genetic engineering. A regulatory part or promoter of one or more genes is combined with a structural gene. The fusion protein is formed after transcription and translation of the fused gene. This type of fusion protein is used in the study of gene regulation or structure-activity relationships. They might also be used clinically as targeted toxins (immunotoxins). (12 Dec 1998) |
| viral fusion proteins | Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells. (12 Dec 1998) |
| fusion proteins, bcr-abl | Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukaemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukaemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in abelson murine leukaemia virus. (12 Dec 1998) |
| fusion proteins, gag-onc | General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells. (12 Dec 1998) |
| fusion proteins, gag-pol | Polyprotein products of a fused portion of retroviral mRNA containing the gag and pol genes. The polyprotein is synthesised only five percent of the time since pol is out of frame with gag, and is generated by ribosomal frameshifting. (12 Dec 1998) |
| recessive oncogene | <molecular biology> A single copy of this gene issufficient to suppress cell proliferation, the loss of both copies of the gene contributes to cancer formation. (09 Oct 1997) |
| viral oncogene | <molecular biology> A viral gene that contributes to cancer development in vertebrate hosts. (09 Oct 1997) |
| cellular oncogene | <molecular biology> A normal gene that, when mutated or improperly expressed, can cause cancer to develop. (09 Oct 1997) |
| c-oncogene | <molecular biology> A normal gene which has a tumour-producing insert that may have originated from a virus in it, turning it into a proto-oncogene. When these genes are sufficiently mutated, amplified, or over-expressed (transcribed too many times), they can begin to produce cancers. (05 Jan 1998) |
| proto-oncogene | <molecular biology> The normal, cellular equivalent of an oncogene, thus usually a gene involved in the signalling or regulation of cell growth. In general, cellular proto-oncogenes are prefixed with a c, rather than their abnormal viral counterparts, that are prefixed with a v, for example c myc and v myc. They are fragments of DNA, related to oncogenes but are the normal switches used to control growth and tissue repair. (06 Oct 1997) |
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| proto-oncogene protein pp60(c-src) | <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. Registry number: EC 2.7.1.- (12 Dec 1998) |