| c-onc | cellular oncogene |
|---|---|
| ONC | oncogene; oncology; Orthopaedic Nursing Certificate; over-the-needle catheter |
| src | Rous sarcoma oncogene |
| V-ONC | viral oncogene |
| proto-oncogene | <molecular biology> The normal, cellular equivalent of an oncogene, thus usually a gene involved in the signalling or regulation of cell growth. In general, cellular proto-oncogenes are prefixed with a c, rather than their abnormal viral counterparts, that are prefixed with a v, for example c myc and v myc. They are fragments of DNA, related to oncogenes but are the normal switches used to control growth and tissue repair. (06 Oct 1997) |
|---|---|
| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| proto-oncogene protein pp60(c-src) | <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. Registry number: EC 2.7.1.- (12 Dec 1998) |
| dominant oncogene | <genetics, molecular biology, oncology> A gene that stimulates cell proliferation and can drastically increase the risk of cancer development when present in a single copy. (09 Oct 1997) |
| immortalising oncogene | <molecular biology> A gene that upon transfectionenables a primary cell to grow indefinitely in culture. (09 Oct 1997) |
| oncogene | <molecular biology, oncology> Mutated and/or overexpressed version of a normal gene of animal cells (the proto-oncogene) that in a dominant fashion can release the cell from normal restraints on growth and thus alone or in concert with other changes, convert a cell into a tumour cell. (18 Nov 1997) |
| oncogene protein gp140(v-fms) | Transforming glycoprotein coded by the fms oncogene from the susan mcdonough strain of feline sarcoma virus (sm-fesv). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (csf-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms). (12 Dec 1998) |
| oncogene protein p21(ras) | Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumours. (12 Dec 1998) |
| oncogene protein p55(v-myc) | Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies. (12 Dec 1998) |
| oncogene protein p65(gag-jun) | Transforming protein coded by jun oncogenes (genes, jun). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. V-jun lacks a negative regulatory domain that regulates transcription in c-jun. (12 Dec 1998) |
| oncogene protein pp60(v-src) | <chemical> Tyrosine-specific protein kinase encoded by the v-src oncogene of rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its n-terminal glycine. Chemical name: Kinase (phosphorylating), protein pp60src (12 Dec 1998) |
| transforming oncogene | <molecular biology> A gene that upon transfection converts a previously immortalised cell to the malignant phenotype. (09 Oct 1997) |
| adenovirus e1a proteins | Proteins transcribed from the e1a region of adenovirus which are involved in positive regulation of transcription of the early genes. (12 Dec 1998) |
| adenovirus e1b proteins | Proteins transcribed from the e1b region of adenovirus which are involved in regulation of the levels of early and late gene expression. (12 Dec 1998) |
| adenovirus e1 proteins | The very first viral gene products synthesised after cells are infected with adenovirus. The e1 region of the genome has been divided into two major transcriptional units, e1a and e1b, each expressing proteins of the same name (adenovirus e1a proteins and adenovirus e1b proteins). (12 Dec 1998) |
Synonyms : Oncogene Products v-mos, Oncogene Proteins mos, p37 v-mos, p85 gag-mos, Fusion Proteins, gag mos, Oncogene Products v mos, Oncogene Proteins v mos, Oncogene Proteins, mos, Products v-mos, Oncogene, Proteins mos, Oncogene, Proteins v-mos, Oncogene, gag-mos, p85
Synonyms : Oncogene Products v-myb, Oncogene Protein myb, Oncogene Proteins myb, v-myb Protein, Oncogene Products v myb, Oncogene Proteins v myb, Oncogene Proteins, myb, myb, Oncogene Protein, myb, Oncogene Proteins, v myb Protein, v myb Proteins, v-myb, Oncogene Products
Synonyms : Oncogene Protein mil, Protein v-mil, v-raf Kinases, Kinases, v-raf, Oncogene Proteins v mil, Oncogene Proteins v raf, Protein mil, Oncogene, Proteins v-raf, Oncogene, mil, Oncogene Protein, v mil Protein, v raf Kinases, v-mil, Oncogene Proteins, v-mil, Protein
Synonyms : Oncogene Products v-rel, Oncogene Protein rel, Oncogene Proteins rel, v-rel Protein, Oncogene Products v rel, Oncogene Proteins v rel, Oncogene Proteins, rel, Protein, v-rel, Proteins, v-rel, rel, Oncogene Protein, rel, Oncogene Proteins, v rel Protein
Synonyms : Oncogene Products v-sis, Oncogene Proteins sis, Oncogene Products v sis, Oncogene Proteins v sis, Oncogene Proteins, sis, Proteins, v-sis, sis, Oncogene Proteins, v sis Proteins, v-sis, Oncogene Products, v-sis, Oncogene Proteins