| oncogenesis | <oncology> The causation or production of tumours. (16 Dec 1997) |
|---|
| proto-oncogene proteins c-mos | Cellular proteins encoded by the c-mos genes (genes, mos). They function in the cell cycle to maintain maturation-promoting factor in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (12 Dec 1998) |
|---|---|
| proto-oncogene proteins c-myc | Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumourigenesis. (12 Dec 1998) |
| proto-oncogene proteins c-raf | <enzyme> A class of serine-threonine kinases involved in cellular signal transduction. Included in this class are the proto-oncogene proteins mil and raf. Raf is a component of a signal transduction pathway leading to increased gene expression through the c-jun DNA binding site, ap1. Registry number: EC 2.7.10.- (12 Dec 1998) |
| dominant oncogene | <genetics, molecular biology, oncology> A gene that stimulates cell proliferation and can drastically increase the risk of cancer development when present in a single copy. (09 Oct 1997) |
| immortalising oncogene | <molecular biology> A gene that upon transfectionenables a primary cell to grow indefinitely in culture. (09 Oct 1997) |
| transforming oncogene | <molecular biology> A gene that upon transfection converts a previously immortalised cell to the malignant phenotype. (09 Oct 1997) |