| oncogene proteins | Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (oncogene proteins, fusion). (12 Dec 1998) |
|---|---|
| oncogene proteins v-abl | Transforming proteins encoded by the abl oncogenes. Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific n-terminal amino acids. (12 Dec 1998) |
| oncogene proteins v-erba | Transforming proteins encoded by erba oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erba, the thyroid hormone receptor (receptors, thyroid hormone) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. V-erba acts as a dominant repressor of c-erba, inducing transformation by disinhibiting proliferation. (12 Dec 1998) |
| oncogene proteins v-erbb | Transforming proteins encoded by erbb oncogenes from the avian erythroblastosis virus. The protein is a truncated form of the egf receptor (receptors, epidermal growth factor-urogastrone) whose kinase domain is constitutively activated by deletion of the ligand-binding domain. (12 Dec 1998) |
| oncogene proteins v-fos | Transforming proteins coded by fos oncogenes. These proteins have been found in the finkel-biskis-jinkins (fbj-msv) and finkel-biskis-reilly (fbr-msv) murine sarcoma viruses which induce osteogenic sarcomas in mice. The fbj-msv v-fos gene encodes a p55 kD protein and the fbr-msv v-fos gene encodes a p75 kD fusion protein. (12 Dec 1998) |
| oncogene proteins v-mos | Transforming proteins coded by mos oncogenes. The v-mos proteins were originally isolated from the moloney murine sarcoma virus (mo-msv). (12 Dec 1998) |
| oncogene proteins, fusion | The translation products of the fusion between an oncogene and another gene. The latter may be of viral or cellular origin. (12 Dec 1998) |
| oncogene proteins, viral | Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities. (12 Dec 1998) |
| oncogenes | Genes which can potentially induce neoplastic transformation. They include genes for growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. When these genes are constitutively expressed after structural and/or regulatory changes, uncontrolled cell proliferation may result. Viral oncogenes have names of the form v-onc; cellular oncogenes (proto-oncogenes) are designated c-onc. (12 Dec 1998) |
| oncogenesis | <oncology> The causation or production of tumours. (16 Dec 1997) |
| oncogenic | Causing, inducing, or being suitable for the formation and development of a neoplasm. Synonym: oncogenic. (05 Mar 2000) |
| oncogenic virus | <oncology, virology> A virus capable of causing cancer in animals or in humans. These include DNA viruses, ranging in size from Papova viruses to Herpes viruses and the RNA containing retroviruses. See: Oncovirinae. (18 Nov 1997) |
| oncogenic viruses | Viruses that produce tumours. (12 Dec 1998) |
| oncogenous | Causing, inducing, or being suitable for the formation and development of a neoplasm. Synonym: oncogenic. (05 Mar 2000) |
| oncograph | <physiology> An instrument for registering the changes observable with an oncometer. Origin: Gr. Bulk + -graph. Source: Websters Dictionary (01 Mar 1998) |