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competitive antagonist An antimetabolite.
(05 Mar 2000)
muscarinic antagonist Drugs which bind with muscarinic cholinergic receptors but do not activate them, thus preventing access to acetylcholine; examples include atropine, scopolamine, propantheline, and pirenzepine.
(05 Mar 2000)
H2 antagonist <pharmacology> A class of anti-ulcer medication which work through the inhibition of basal and nocturnal gastric acid secretion by competitive inhibition of the action of histamine at histamine H2 receptor sites on the parietal cells.
Drugs of this type block gastric acid secretion and are therefore clinically useful in treating duodenal ulcers.
Examples include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac).
(27 Sep 1997)
insulin antagonist Something that opposes or fights the action of insulin. Insulin lowers the level of glucose (sugar) in the blood, whereas glucagon raises it, therefore, glucagon is an antagonist of insulin.
(09 Oct 1997)
enzyme antagonist An antimetabolite or inhibitor of enzyme action.
(05 Mar 2000)
folate antagonist <pharmacology> One of a group of substances which blocks the formation of nucleotides that require the presence of folate (one of the B vitamins) before they can be made. The substance does this by blocking key steps in the reaction sequence. These substances are often used to treat cancer because fast-growing cancerous cells usually need to use the blocked reactions more than normal cells.
(09 Oct 1997)
folic acid antagonist <pharmacology> A chemical which inhibits a cells capacity to use folic acid and so prevent cell division, for example methotrexate.
See: chemotherapy.
(12 Nov 1997)
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