| cGMP | cyclic guanosine monophosphate |
|---|---|
| CRE | cumulative radiation effect; cyclic adenosine monophosphate-response element |
| CREM | center for rural emergency medicine; cyclic adenosine monophosphate-response element modulator |
| NcAMP | nephrogenous cyclic adenosine monophosphate |
| PRKAR | protein kinase, cyclic adenosine monophosphate-dependent, regulatory |
| nucleoside diphosphate | The pyrophosphoric ester of a nucleoside, i.e., a nucleoside in which the H of one of the ribose hydroxyls (usually the 5') is replaced by a pyrophosphoric (diphosphoric) radical; e.g., adenosine 5'-diphosphate. Compare: nucleoside bisphosphate. (05 Mar 2000) |
|---|---|
| nucleoside-diphosphate kinase | <enzyme> A phosphotransferase enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyses reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside diphosphate, e.g., UDP, to form ADP and UTP. Many nucleoside diphosphates can act as acceptor, while many ribonucleoside triphosphates and deoxyribonucleoside triphosphates can act as a donor. Chemical name: ATP:nucleoside-diphosphate phosphotransferase Registry number: EC 2.7.4.6 (12 Dec 1998) |
| nucleoside-diphosphate sugars | Nucleoside diphosphates linked through the 5'-diphosphoric group with simple or complex carbohydrates; e.g., GDP-mannose, UDP-glucose (UDPG), dTDP-glucosamine. (05 Mar 2000) |
| nucleoside-diphosphosugar NAD+ 2-hexosyloxidoreductase | <enzyme> Oxidises udp-galactose to udp-2-ketogalactose Registry number: EC 1.1.1.- (26 Jun 1999) |
| nucleoside-diphosphosugar pyrophosphatase | <enzyme> Catalyses the conversion of xdp-sugar to xmp and sugar 1-phosphate Registry number: EC 3.6.1.- Synonym: ndp-sugar pyrophosphatase, nucleotide-sugar pyrophosphatase (26 Jun 1999) |
| nucleoside-phosphate kinase | <enzyme> An enzyme that catalyses reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., ump, to form ADP and udp. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. Chemical name: ATP:nucleoside-phosphate phosphotransferase Registry number: EC 2.7.4.4 (12 Dec 1998) |
| nucleoside phosphorylase | <enzyme> From klebsiella sp.; acts on both purine and pyrimidine nucleosides and catalyses the production of araa from uridine arabinoside (arau) and adenine Registry number: EC 2.4.2.- (26 Jun 1999) |
| nucleoside phosphorylases | Enzymes that catalyze the phosphorolysis of a nucleoside, forming the free purine or pyrimidine plus ribose (or deoxyribose 1-phosphate); e.g., purine-nucleoside phosphorylases. (05 Mar 2000) |
| nucleoside q | <chemical> (1s-(1 alpha,4 beta,5 beta))-2-amino-5-(((4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-7-beta-d-ribofuranosyl-4h-pyrrolo(2,3-d)pyrimidin-4-one. A modified nucleoside which is present in the first position of the anticodon of trna-tyrosine, trna-histidine, trna-asparagine and trna-aspartic acid of many organisms. It is believed to play a role in the regulatory function of trna. Nucleoside q can be further modified to nucleoside q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety. Chemical name: 4H-Pyrrolo(2,3-d)pyrimidin-4-one, 2-amino-5-(((4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-7-beta-D-ribofuranosyl-, (1S-(1alpha,4beta,5beta))- (12 Dec 1998) |
| nucleoside-triphosphatase | <enzyme> Hydrolyzes various nucleotides to a nucleotide diphosphate + pi; inhibited by ca + ATP Registry number: EC 3.6.1.15 Synonym: nucleoside triphosphate phosphohydrolase, nucleoside triphosphatase, ntpase, nuclear envelope nucleoside triphosphatase, nuclear scaffold nucleoside triphosphatase, ns ntpase, nucleosidetriphosphatase (26 Jun 1999) |
| nucleoside triphosphate | A nucleoside in which the H of one of the ribose hydroxyls (usually the 5') is replaced by a triphosphoric group, -PO(OH)-O-PO(OH)-O-PO(OH)2; e.g., adenosine triphosphate. (05 Mar 2000) |
| nucleoside triphosphate-adenylate kinase | <enzyme> Other nucleoside triphosphates may replace GTP as substrate Registry number: EC 2.7.4.10 Synonym: GTP-AMP phosphotransferase, AMP-GTP phosphotransferase (26 Jun 1999) |
| adenosine monophosphate | <chemical> Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. Chemical name: 5'-Adenylic acid (12 Dec 1998) |
| pentose monophosphate shunt | <biochemistry> A pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a pentose phosphate. Diverges from this when glucose-6-phosphate is oxidized to ribose 5 phosphate by the enzyme glucose-6 phosphate dehydrogenase. This step reduces NADP to NADPH, generating a source of reducing power in cells for use in reductive biosyntheses. In plants, part of the pathway functions in the formation of hexoses from carbon dioxide in photosynthesis. Also important as source of pentoses, for example for nucleic acid biosynthesis. This pathway is the main metabolic pathway in neutrophils, congenital deficiency in the pathway produces sensitivity to infection. Alternative metabolic route to Embden Meyerhof pathway for breakdown of glucose. (18 Nov 1997) |
| guanosine 5'-monophosphate | A major component of ribonucleic acids. Synonym: guanine ribonucleotide, guanosine 5'-monophosphate. Guanylic acid reductase (GMP reductase), an enzyme that catalyses the reaction of GMP with NADPH producing IMP, NH3, and NADP+; a part of the purine salvage pathway. Guanylic acid synthetase (GMP synthetase), an enzyme catalyzing the reaction of l-glutamine, XMP, and ATP to produce GMP, l-glutamate, AMP, and pyrophosphate; a key step in purine biosynthesis. Acronym: GMP (05 Mar 2000) |