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MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 2
  • Multiple Endocrine Neoplasia Type 1 - »õâ A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
    Synonyms : MEA 1, MEA I, MEN I, MEN1, Multiple Endocrine Neoplasia Type I, Multiple Endocrine Neoplasms Type 1, Neoplasms, Multiple Endocrine Type I
  • Multiple Endocrine Neoplasia Type 2a - »õâ A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
    Synonyms : MEA 2a, MEA II, MEA IIa, MEN II, MEN IIa, MEN2a, Multiple Endocrine Neoplasia Type 2, Multiple Endocrine Neoplasms Type 2a
  • Multiple Endocrine Neoplasia Type 2b - »õâ Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
    Synonyms : MEA 2b, MEA IIb, MEN III, MEN IIb, MEN2b, Mucosal Neuroma Syndrome, Multiple Endocrine Neoplasms Type 2b, Neuroma Syndrome, Mucosal
  • Multiple Myeloma - »õâ A malignant tumor of plasma cells usually arising in the bone marrow; characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria, and anemia.
    Synonyms : Multiple Myelomas, Myeloma, Multiple, Myeloma, Plasma Cell, Myelomas, Multiple, Myelomas, Plasma-Cell, Plasma-Cell Myeloma, Plasma-Cell Myelomas
  • Multiple Organ Failure - »õâ A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
    Synonyms : Failure, Multiple Organ, Multiple Organ Failures
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MeSH(Medical Subject Headings) À¯»ç °Ë»ö (http://www.nlm.nih.gov) °á°ú : 0 ÆäÀÌÁö: 2
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