| MELAS Syndrome | 1. Mitochondrial Encephalomyopathy 2. Lactic Acidosis 3. S... |
|---|---|
| GOTM | glutamic-oxaloacetic transaminase, mitochondrial |
| LIMM | lethal infantile mitochondrial myopathy |
| MA | malignant arrhythmia; management and administration; mandelic acid; masseter; Master of Arts; matern... |
| MELAS | mitochondrial encephalomyopathy-lactic acidosis- and stroke-like symptoms [syndrome] |
| mt DNA | Mitochondrial DNA |
|---|---|
| MELAS | Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes |
| MELAS | Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes |
| MPT | Mitochondrial Permeability Transition |
| MBR | Mitochondrial benzodiazepine receptors |
| mitochondrial swelling | Increase in volume of mitochondria due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria. (12 Dec 1998) |
|---|---|
| disease, mitochondrial | Mutations (changes) in the mitochondrial chromosome are responsible for a number of disorders including an eye disease (Leber's hereditary optic atrophy), a type of epilepsy (called MERRF which stands for Myoclonus Epilepsy with Ragged Red Fibres), and a cause of dementia (called MELAS for Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes). All mitochondrial diseases were entirely enigmatic before it was discovered that they were due to mutations not in regular chromosomes but the mitochondrial chromosome. (12 Dec 1998) |
| DNA, mitochondrial | Double-stranded DNA of mitochondria. In eukaryotes, the mitochondrial genome is circular and codes for ribosomal rnas, transfer rnas, and about 10 proteins. (12 Dec 1998) |
| alternative inheritance | Galton's term for an assumed form in which all the characters are derived from one parent. (05 Mar 2000) |
| blending inheritance | Galton's term for inheritance in which no component is conspicuous or obtrusive. (05 Mar 2000) |
| galtonian inheritance | Inheritance in which a measurable phenotype is generated by many loci, the contributions of which are statistically independent, additive, and of about equal value. (The latter are in accordance with the classical central limit therein and justify the use of the multivariate normal distribution in galtonian genetics). Synonym: polygenic inheritance. (05 Mar 2000) |
| recessive inheritance | dominance of traits |
| maternal inheritance | Inheritance through the maternal cell line, for example through the oocyte and eggs. Mitochondrial genes are maternally inherited and various other nonMendelian forms of inheritance may also appear as maternal inheritance. (18 Nov 1997) |
| Mendelian inheritance | <genetics> Inheritance of characters according to the classical laws formulated by Gregor Mendel, which give the classic ratios of segregation in the F2 generation. In sexually reproducing organisms, any process of heredity explicable in terms of chromosomal segregation, independent assortment and homologous exchange. (18 Nov 1997) |
| Mendelian Inheritance in Man | A standard, comprehensive, perpetually updated reference source for traits in humans that have been shown to be mendelian or that are thought on reasonable grounds to be so. Each entry has a six-digit catalog number. Those securely established (by molecular biology or by extensive clinical studies) are marked with an asterisk. (05 Mar 2000) |
| codominant inheritance | Inheritance in which two alleles are individually expressed in the presence of each other; there may be other alleles available at the locus that may or may not exhibit codominance. (05 Mar 2000) |
| collateral inheritance | The appearance of characters in collateral members of a family group, as when an uncle and a niece show the same character inherited from a common ancestor; in recessive characters it may appear irregularly, in contrast to dominant characters transmitted directly from one generation to the next. (05 Mar 2000) |
| mosaic inheritance | Inheritance in which the paternal influence is dominant in one group of cells and the maternal in another. Compare: lyonization. (05 Mar 2000) |
| multifactorial inheritance | Type of hereditary pattern seen with a combination of genetic factors, sometimes with environmental influence. Skin colour, for example, is multifactorially determined. (12 Dec 1998) |
| polygenic inheritance | Inheritance in which a measurable phenotype is generated by many loci, the contributions of which are statistically independent, additive, and of about equal value. (The latter are in accordance with the classical central limit therein and justify the use of the multivariate normal distribution in galtonian genetics). Synonym: polygenic inheritance. (05 Mar 2000) |