| MBD | Marchiafava-Bignami disease; Mental Deterioration Battery; methylene blue dye; minimal brain damage;... |
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| MCD | magnetic circular dichroism; mast-cell degranulation; mean cell diameter; mean of consecutive differ... |
| MPD | main pancreatic duct; maximum permissible dose; mean population doubling; membrane potential differe... |
| FIC | Fogarty International Center; fractional inhibitory concentration |
| IC50 | inhibitory concentration of 50% |
| minimal infecting dose | <microbiology> The smallest quantity of infectious material regularly producing infection; usually expressed as I.D.50, the quantity causing infection in 50% of a suitable series of animals or cells (cell cultures). (05 Mar 2000) |
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| minimal lethal dose | <pharmacology> The minimal dose of a toxic substance or infectious agent that is lethal, as assayed in various experimental animals (e.g., the least amount of diphtheria toxin that, on an average, kills a 250-g guinea pig within 96 hours after subcutaneous inoculation). When followed by a subscript (generally "MLD50"), denotes the minimal dose that is lethal to a certain percentage (e.g., 50%) of animals so assayed, LD05. See: lethal dose. (05 Mar 2000) |
| minimal medium | <cell culture> The simplest tissue culture medium that will support the proliferation of normal cells. (18 Nov 1997) |
| minimal reacting dose | The minimal dose of a toxic substance causing a reaction, as manifested in the skin of a series of susceptible test animals; the assay is based on the development of a characteristic, minimal but definite, "standard," focal inflammation (congestion and oedema, induration, degenerative changes, and desquamation of epidermal cells). (05 Mar 2000) |
| inhibitory | Of or pertaining to, or producing, inhibition; consisting in inhibition; tending or serving to inhibit; as, the inhibitory action of the pneumogastric on the respiratory center. "I would not have you consider these criticisms as inhibitory. <physiology> " (Lamb) Inhibitory nerves, those nerves which modify, inhibit, or suppress a motor or secretory act already in progress. Origin: LL. Inhibitorius: cf. F. Inhibitoire. Source: Websters Dictionary (01 Mar 1998) |
| inhibitory fibres | Nerve fibre's that inhibit the activity of the nerve cells with which they have synaptic connections, or of the effector tissue (smooth muscle, heart muscle, glands) in which they terminate. (05 Mar 2000) |
| inhibitory junction potential | Hyperpolarization of smooth muscle produced by stimulation of inhibitory nerves. (05 Mar 2000) |
| inhibitory-motor | <physiology> A term applied to certain nerve centers which govern or restrain subsidiary centers, from which motor impressions issue. Source: Websters Dictionary (01 Mar 1998) |
| inhibitory nerve | <anatomy, nerve> A nerve conveying impulses that diminish functional activity in a part. (05 Mar 2000) |
| inhibitory postsynaptic potential | The change in potential produced in the membrane of the next neuron when an impulse which has an inhibitory influence arrives at the synapse; it is a local change in the direction of hyperpolarization; the frequency of discharge of a given neuron is determined by the extent to which impulses that lead to excitatory postsynaptic potential's predominate over those that cause inhibitory postsynaptic potential's. (05 Mar 2000) |
| inhibitory synapse | A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. The most common inhibitory neurotransmitter is GABA, this opens channels in the postsynaptic cell which tend to stabilise its resting potential, thus rendering it less likely to fire. See: excitatory synapse, presynaptic inhibition, postsynaptic inhibition. (18 Nov 1997) |
| Leukaemia inhibitory factor | <growth factor> Polypeptide growth factor or cytokine with wide range of activities. Regulates growth and differentiation of primordial germ cells and embryonic stem cells but has effects on peripheral neurons, osteoblasts, adipocytes and various cells of the myeloid lineage. Given to adult animals induces weight loss, behavioural disorders and bone abnormalities. Many of the effects of LIF in vitro can be mimicked by IL-6, oncostatin M and ciliary neurotrophic factor, all of which interact indirectly with gp130, a shared tranducer subunit. (18 Nov 1997) |
| leukocyte migration-inhibitory factors | Protein factor(s) released by sensitised lymphocytes (and possibly other cells) that inhibit the movement of leukocytes, especially polymorphonuclear cells, away from their site of release. Assays for these factors are used as tests for cellular immunity. Two of the common assays are the leukocyte migration capillary tube technique (lmct) and the leukocyte migration agarose technique (lmat). (12 Dec 1998) |
| M concentration | The maximum number of bacterial cells which can be produced in a unit volume of growth medium. (05 Mar 2000) |
| mean corpuscular haemoglobin concentration | Hgb/Hct;the average haemoglobin concentration in a given volume of packed red cells, calculated from the haemoglobin therein and the haematocrit, in erythrocyte indices. (05 Mar 2000) |