| LR | labeled release; laboratory references; laboratory report; labor room; lactated Ringer [solution]; l... |
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| MLAEP | middle latency auditory evoked potential |
| ERA | electrical response activity; electroencephalic response audiometry; Electroshock Research Associati... |
| RR | radiation reaction; radiation response; rate ratio; rational recovery [group]; recovery room; relati... |
| MEC | median effective concentration; middle ear canal; middle ear cell; minimum effective concentration |
| partial response | <oncology> A decrease of at least 50 percent in the sum of the measurements of all evaluable target lesions or tumours seen in a study. (16 Dec 1997) |
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| relaxation response | An integrated hypothalamic reaction resulting in decreased sympathetic nervous system activity which, physiologically and psychologically, is almost a mirror image of the body's response's to Cannon's emergency theory (flight or fight response); can be self-induced through the use of techniques associated with transcendental meditation, yoga, and biofeedback. See: emergency theory. (05 Mar 2000) |
| response | An action or movement due to the application of a stimulus. Origin: L. Respondere = to answer, reply (18 Nov 1997) |
| response generalisation | <biology> The principle that after an organism learns to respond in a particular manner to a stimulus, that stimulus is effective in eliciting similar responses. (12 Dec 1998) |
| response hierarchy | Alternative reactions or modes of adjustment to a given situation arranged in the probable order of prior effectiveness; e.g., a mother attempting to discipline an unruly child may first request, cajole, then plead, scold, and finally punish; her behaviours can be ordered along a response hierarchy for further monitoring of effectiveness. (05 Mar 2000) |
| response rate | <oncology> The percentage of patients showing partial or complete response to the given treatment. (16 Dec 1997) |
| graft-versus-host response | <haematology> A common and serious, complication of bone marrow transplantation where there is a reaction of donated bone marrow against a patient's own tissue. When donor lymphocytes or a graft containing lymphocytes that are immunologically competent are given to a patient that has low immunological competence, an incompatibility reaction can result. This is due to antibodies from the donor against antigens in the host. This is due to mismatch of MHC Class I antigens and can produce lymphocyte clones that will react by a variety of processes against the host and cause damage. The clinical condition can be fatal and is due to the donor's immune cells recognising the host cells as foreign. The clinical entity characterised by anorexia, diarrhoea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the graft-versus-host reaction. It can occur in either chronic or acute forms and is treatable by immunosuppressive drugs. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin. Radiological appearances of the gastrointestinal tract include; thickened wall, mucosal folds thickened or effaced, increased secretions most likely to be rapid transit of GI tract, mass most likely to be focal oedema, fibrosis, hallmark: diffuse, uniform thickening of small bowel. Synonym: GVH disease. Acronym: GVHD (20 Sep 2002) |
| complete response | <oncology> The disappearance of all clinical evidence of disease. Unfortunately, this does not necessarily mean cure, as microscopic metastases may remain undetected, are likely to regrow and become resistant to treatment. May also be used in relation to a pathological specimen, where no residual abnormality can be detected in the specimen, in which cas it is referred to as a pathological complete reponse. Acronym: CR (16 Mar 1998) |
| concentration-response curve | <pharmacology> This is a graph produced to show the relation between the exposure concentration of a drug (or other chemical) and the degree of response it produces, as measured by the percentage of the exposed population showing a defined, often quantal, effect. (05 Jan 1998) |
| conditioned response | A response already in an individual's repertoire but which, through repeated pairings with its natural stimulus, has been acquired or conditioned anew to a previously neutral or conditioned stimulus. See: conditioning. Compare: unconditioned response. (05 Mar 2000) |
| Cushing response | A rise in systemic blood pressure when the intracranial pressure acutely increases, usually in excess of 50% of the systolic arterial pressure. Synonym: Cushing effect, Cushing response. (05 Mar 2000) |
| primary antibody response | <immunology> Antibodies made upon first exposure to an antigen, mostly of the class IgM. (05 Mar 1998) |
| primary immune response | <immunology> The immune response to the first challenge by a particular antigen. Usually less extensive than the secondary immune response, being slower and shorter lived with smaller amounts of lower affinity antibody being produced. (18 Nov 1997) |
| heat-shock response | <cell biology> A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (12 Dec 1998) |
| heat-shock response element | <cell biology, protein> The nucleotide sequence, CNNGAANNTCCNG, which is in the promoter region of the heat-shock genes. When the animal is exposed to certain types of stress such as a sudden rise in temperature, the first thing that happens to activate these genes is the binding of the HSE by a transcriptional enhancer protein. (09 Oct 1997) |