| bone sclerosis | <medicine> A condition of bone cartilage occurring in certain diseases of these tissues, in which they acquire an unnatural density, and come to resemble ivory. Origin: L. Eburnus of ivory, fr. Ebur ivory: cf. F. Eburnation. See Ivory. Source: Websters Dictionary (01 Mar 1998) |
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| Canavan's sclerosis | Autosomal recessive degenerative disease of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See: leukodystrophy. Synonym: Canavan's sclerosis, Canavan-van Bogaert-Bertrand disease, spongy degeneration of infancy. (05 Mar 2000) |
| valvular sclerosis | Fibrosis, often with calcification of valves, considered to be an aging change and not due to primary valvular disease. (05 Mar 2000) |
| vascular sclerosis | <cardiology, disease> Imprecise term for various disorders of arteries, particularly hardening due to fibrosis or calcium deposition, often used as a synonym for atherosclerosis. (17 Oct 1997) |
| mantle sclerosis | A common cerebral lesion in the palsied states of early life characterised by nodular cortical atrophy. (05 Mar 2000) |
| glomerular sclerosis | Hyaline deposits or scarring within the renal glomeruli, a degenerative process occurring in association with renal arteriosclerosis or diabetes. Synonym: glomerular sclerosis. Origin: Glomerulus + G. Sklerosis, hardness (05 Mar 2000) |
| central areolar choroidal sclerosis | A slowly progressive pigmentary degeneration in young persons; characterised by black foci closely set together and coalescent at the posterior pole and macular region. Synonym: central areolar choroidal atrophy, central areolar choroidal sclerosis. (05 Mar 2000) |
| cerebral sclerosis, diffuse | Diffuse progressive degeneration of the white matter of the brain, accompanied by mental deterioration, severe motor disturbances, and early death. (12 Dec 1998) |
| physiologic sclerosis | A slowly progressive sclerosis in the walls of the ovarian arteries which commences after puberty. Synonym: menstrual sclerosis, ovulational sclerosis. (05 Mar 2000) |
| Monckeberg's sclerosis | Arterial sclerosis involving the peripheral arteries, especially of the legs of older people, with deposition of calcium in the medial coat (pipestem arteries) but with little or no encroachment on the lumen. Synonym: medial arteriosclerosis, Monckeberg's calcification, Monckeberg's degeneration, Monckeberg's medial calcification, Monckeberg's sclerosis. (05 Mar 2000) |
| combined sclerosis | A subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterised by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns. Synonym: combined sclerosis, combined system disease, funicular myelitis, Putnam-Dana syndrome, vitamin B12 neuropathy. (05 Mar 2000) |
| multiple sclerosis | <neurology> Neurodegenerative disease characterised by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in 3rd or 4th decade with intermittent progression over an extended period. Cause still uncertain. (18 Nov 1997) |
| posterior sclerosis | See Tabes dorsalis. (12 Dec 1998) |
| posterior spinal sclerosis | See Tabes dorsalis. (12 Dec 1998) |
| primary lateral sclerosis | Considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia, and Babinski signs are present, but not fasciculation potentials, nor any electrodiagnostic evidence of a lower motor neuron lesion. Synonym: lateral spinal sclerosis. (05 Mar 2000) |