| 영문 | bone marrow transplantation | 한글 | 골수이식 |
|---|---|---|---|
| 설명 | 환자의 병든 골수 대신 건강한 골수세포를 이식하는 처치-암치료에 방사선요법이나 화학요법을 썼을 경우 그 부작용으로 골수의 기능이 극도로 나빠졌을 때나 또는 백혈병의 경우에 면역요법으로 이용된다. 방법은 건강한 골수액을 채취하여 인산완충액을 섞은 링거액에 부유시켜 여과한 다음 정맥에 주사한다. 주입한 골수가 체내에 착상하여 번식하기 쉽게 할 목적으로 미리 X선을 조사하여 이식받는 환자의 항체기능을 억제해 둘 필요가 있다. 이 조작은 급성 방사능증을 일으키기 때문에 여러 가지 보호치료가 필요하다. 그러나 골수를 이식하면 급성 방사능증을 가볍게 넘길 수 있다고 하여 반대로 방사능을 대량으로 조사받은 사람에게 그 치료법으로 이용되기도 한다. 이식에는 스스로의 골수세포를 미리 채취해 놓고 후에 자신에게 주입하는 자가이식과 일란성쌍둥이의 한쪽에서 골수세포를 주입하는 동계이식 및 조직적합항원이 일치한 타인의 골수세포를 주입하는 동종이식이 있다. 대상병으로 백혈병, 재생불량빈혈, 선천면역결핍증 등이 있다. 일반적으로 강력한 면역억제제의 투여가 필요하다. 부작용으로서는 골수이식 후 이식편대숙주병, 기회감염 등이 있다. |
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| 영문 | red bone marrow | 한글 | 적색골수 |
|---|---|---|---|
| 설명 | 분화중의 갈비뼈, 척추뼈나 그 외의 많은 작은 뼈에 있는 활동성 골수이다. 적혈구나 과립백혈구의 생산 장소이다. |
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| TBNA | Trans-Bronchial Needle Aspiration |
|---|---|
| TTA | Trans-Tracheal Aspiration |
| AAS | Aarskog-Scott [syndrome]; acid aspiration syndrome; alcoholic abstinence syndrome; American Academy ... |
| ABC | absolute basophil count; absolute bone conduction; acalculous biliary colic; acid balance control; a... |
| AP | accessory pathway; accounts payable; acid phosphatase; acinar parenchyma; action potential; active p... |
| autologous bone marrow transplant | <haematology, procedure> A process in which a patients healthy bone marrow is withdrawn and preserved. It is later injected back into the patient to replace bone marrow damaged by high doses of radiation therapy. It can then produce healthy blood cells. This treatment is used to offset the detrimental effects of high-dose radiation used in certain types of cancer. (31 Dec 1997) |
|---|---|
| bone marrow | <haematology> The soft, spongy tissue found in the centre of most large bones that produces the cellular components of blood: white cells, red cells and platelets (haemopoiesis). It is also the most radiation sensitive tissue of the body. (12 May 1997) |
| bone marrow aspirate | <procedure> A small volume of bone marrow removed under local or general anaesthetic from either the hip bone (pelvis) or breast bone (sternum). The cells in the sample can then be examined under the microscope to identify any abnormality in the developing blood cells. (13 Nov 1997) |
| bone marrow biopsy | <procedure> A test involving the insertion of a thin needle into the breastbone or more commonly, the hip, in order to aspirate a sample of the marrow. A small piece of cortical bone may also be obtained for biopsy. Anaemia of unknown cause is often investigated using this test. (27 Sep 1997) |
| bone marrow cells | The fat cells (adipocytes), large nucleated cells or myelocytes, and giant cells called megakaryocytes, filling the meshes making up the bone marrow, a meshwork of connective tissue containing branching fibres. (12 Dec 1998) |
| bone marrow dose | The cumulative dose to the blood-forming organ from therapeutic or nuclear fallout irradiation; the presumed leukemogenic dose. (05 Mar 2000) |
| bone marrow embolism | Obstruction of a vessel by bone marrow, usually following fracture of a bone. (05 Mar 2000) |
| bone marrow examination | Removal of bone marrow and evaluation of its histologic picture. (12 Dec 1998) |
| bone marrow harvesting | <procedure> A medical procedure which involves collecting healthy bone marrow which willbe stored and used in a future bone marrow transplant. (09 Oct 1997) |
| bone marrow neoplasms | Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as myeloma. most bone marrow neoplasms are metastatic. (12 Dec 1998) |
| bone marrow purging | Techniques for the removal of subpopulations of cells (usually residual tumour cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic bone marrow transplantation. (12 Dec 1998) |
| bone marrow suppression | <oncology, pharmacology> A side effect of many anticancer and antiviral drugs, including AZT. Bone marrow suppression leads to a decrease in white blood cells, red blood cells and platelets. Such reductions in turn result in anaemia, bacterial infections and spontaneous or excess bleeding. (09 Oct 1997) |
| bone marrow transplant | <procedure> A procedure in which a section of bone marrow is taken from one person and transplanted into another. It is used to replace bone marrow that has been damaged or diseased. It can be a treatment option in leukaemia. Acronym: BMT (16 Dec 1997) |
| bone marrow transplantation | <oncology, procedure> Treatment in which healthy bone marrow replaces bone marrow that has been affected by a disease or by treatment for a disease. Acronym: BMT (12 May 1997) |
| marrow | 1. <anatomy> The tissue which fills the cavities of most bones; the medulla. In the larger cavities it is commonly very fatty, but in the smaller cavities it is much less fatty, and red or reddish in colour. 2. The essence; the best part. "It takes from our achievements . . . The pith and marrow of our attribute." (Shak) 3. [OE. Maru, maro; perh. A different word; cf. Gael. Maraon together] One of a pair; a match; a companion; an intimate associate. "Chopping and changing I can not commend, With thief or his marrow, for fear of ill end. <botany>" (Tusser) Marrow squash See Spinal cord, under Spinal. Origin: OE. Marou, mary, maruh, AS. Mearg, mearh; akin to OS. Marg, D. Merg, G. Mark, OHG. Marg, marag, Icel. Mergr, Sw. Merg, Dan. Marv, Skr. Majjan; cf. Skr. Majj to sink, L. Mergere. Cf. Merge. Source: Websters Dictionary (01 Mar 1998) |