| antihemophilic globulin A | A coagulation (clotting) factor. Classic haemophilia (haemophilia A) is due to a congenital deficiency in the amount (or activity) of factor VIII. Factor VIII is also known as antihemophiliac factor (AHF) or antihemophiliac globulin (AHG). The gene for factor VIII (that for classic haemophilia) is on the X chromosome so females can be silent carriers without symptoms and males can be haemophiliacs. (12 Dec 1998) |
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| antihemophilic globulin B | <chemical> Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, ixa, forms a complex with factor viii and calcium on platelet factor 3 to activate factor x to xa. Deficiency of factor ix results in christmas disease (haemophilia b). Chemical name: Blood-coagulation factor IX (12 Dec 1998) |
| antihuman globulin | Serum from a rabbit or other animal previously immunised with purified human globulin to prepare antibodies directed against IgG and complement; used in the direct and indirect Coombs' tests. Synonym: Coombs' serum. (05 Mar 2000) |
| antilymphocyte globulin | <protein> Antibodies which attach to and destroy lymphocytes. This may be used clinically by injection into a vein, for example in aplastic anaemia. (13 Nov 1997) |
| b1C globulin | The third component (C3) of complement. See: component of complement. (05 Mar 2000) |
| b1E globulin | The fourth component (C4) of complement. See: component of complement. (05 Mar 2000) |
| b1F globulin | The fifth component (C5) of complement. See: component of complement. (05 Mar 2000) |
| gamma globulin | <immunology> A non-specific immunoglobulin (antibody) administered for the purpose of passive immunity. A common example is hepatitis A prophylaxis. (27 Sep 1997) |
| globulin | <protein> A simple globular protein which cannot be dissolved in pure water but which can be dissolved if a salt is added to the water. It can also be precipitated out of solution and into a solid with a solution of ammonium sulphate at 50% saturation. Examples of globulin proteins are immunoglobulin and cryoglobulin. (14 Oct 1997) |
| gonadal steroid-binding globulin | A protein that transports 65% of the testosterone in plasma. Synonym: sex steroid-binding globulin. (05 Mar 2000) |
| cold insoluble globulin | <haematology> Name, now obsolete, originally given to fibronectin prepared from cryoprecipitate. (18 Nov 1997) |
| plasma accelerator globulin | <chemical> Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor v accomplishes this by forming a complex with factor xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor v leads to owren's disease. Chemical name: Blood-coagulation factor V (12 Dec 1998) |
| corticosteroid-binding globulin | <chemical> Chemical name: Transcortins (12 Dec 1998) |
| progesterone-binding globulin | A glycoprotein migrating as alpha 1-globulin, molecular weight 70,000 to 120,000. The protein, which is present in increased amounts in the plasma during pregnancy, binds mainly progesterone, with other steroids including testosterone competing weakly. (12 Dec 1998) |
| human gamma globulin | A preparation of the proteins of liquid human plasma, containing the antibodies of normal adults; it is obtained from pooled liquid human plasma from a number of donors and may be prepared by precipitation with organic solvents under controlled conditions of pH, ionic strength, and temperature. Synonym: human normal immunoglobulin. (05 Mar 2000) |