| BLRC | Biomedical Library Review Committee |
|---|---|
| DFL | digital film library |
| FLICC | Federal Library and Information Center Committee |
| HELLIS | Health, Literature, Library and Information Services |
| HELP | Hawaii early learning profile; Health Education Library Program; Health Emergency Loan Program; Heal... |
| drug screening | Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. (12 Dec 1998) |
|---|---|
| drug screening assays, antitumour | Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumour growth parameters in laboratory animals. (12 Dec 1998) |
| familial screening | Screening directed at close relatives of probands with diseases that may lie latent, as in age-dependent dominant traits, or that may involve risk to progeny, as X-linked traits. (05 Mar 2000) |
| arrayed library | <molecular biology> Individual primary recombinant clones (hosted in phage, cosmid, YAC, or other vector) that are placed in two-dimensional arrays in microtiter dishes. Each primary clone can be identified by the identity of the plate and the clone location (row and column) on that plate. Arrayed libraries of clones can be used for many applications, including screening for a specific gene or genomic region of interest as well as for physical mapping. Information gathered on individual clones from various genetic linkage and physical map analyses is entered into a relational database and used to construct physical and genetic linkage maps simultaneously, clone identifiers serve to interrelate the multilevel maps. Compare: library, genomic library. (19 Jan 1998) |
| gene library | <molecular biology> A collection of cloned DNA fragments that contains all the genetic information of a particular organism. (09 Oct 1997) |
| genomic library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
| cDNA library | <molecular biology> A collection of all of the mRNA molecules present in a cell or organism, all turned into cDNA molecules with the enzyme reverse transcriptase, then inserted into vectors (other DNA molecules which can continue to replicate after addition of foreign DNA). The library can then be probed for the specific cDNA (and thus mRNA) of interest. (09 Oct 1997) |
| peptide library | A collection of cloned free peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide. (12 Dec 1998) |
| complementary DNA library | <molecular biology> A collection of all of the mRNA molecules present in a cell or organism, all turned into cDNA molecules with the enzyme reverse transcriptase, then inserted into vectors (other DNA molecules which can continue to replicate after addition of foreign DNA). The library can then be probed for the specific cDNA (and thus mRNA) of interest. (09 Oct 1997) |
| national library of medicine | An agency of the national institutes of health concerned with overall planning, promoting, and administering programs pertaining to various aspects of documentation and library services in the field of medicine. (12 Dec 1998) |
| DNA library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
| epitope library | <molecular biology> Large collection (hundreds of millions) of peptides each encoded by a randomly mutated piece of DNA in a phage genome and expressed on the surface of that bacteriophage, sometimes as an N terminal extension of a coat protein. Particular phages can be selected by a binding assay and since the peptide has its encoding DNA associated with it sequencing is straightforward. (18 Nov 1997) |
| expression library | <molecular biology> A library of DNA fragments which was created with an expression vector so that any genes present in the library are expressed. (09 Oct 1997) |
| library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
| library administration | Planning, organizing, staffing, direction, and control of libraries. (12 Dec 1998) |