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plaster model
| lethal dose | <pharmacology> The amount, or dosage, of a toxin necessary to cause death. (16 Mar 1998) |
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| lethal dose 50 | <pharmacology> The amount, or dosage, of a toxin necessary to kill 50% of the experimental subjects. (16 Mar 1998) |
| lethal dwarfism | Dwarfism leading to intrauterine or neonatal death. (05 Mar 2000) |
| lethal equivalent | A combination of selective effects that on average have the same impact on the composition of the gene pool as one death; e.g., two carriers at 50% risk of dying would be the lethal equivalent of one carrier at 100% risk, in the population genetics of recessive traits lethal equivalent is expressed as twice the sum of the expected number of deaths ascribable to the genetic load. Expression used of the genetic load of recessive genes in heterozygous state that if in homozygous state would cause death or carry a risk of death. The expected number of deaths from all such genes is expressed in lethal equivalent. (05 Mar 2000) |
| lethal factor | A disorder that prevents effective reproduction by those affected; e.g., Klinefelter syndrome. (05 Mar 2000) |
| lethal gene | A gene that produces a genotype that leads to death of the organism before reproduction is possible or that precludes reproduction; for a recessive gene the homozygous or hemizygous state is lethal. (05 Mar 2000) |
| lethal midline granuloma | Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases. An obsolete term for polymorphic reticulosis. Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma. (05 Mar 2000) |
| Adair-Koshland-Nemethy-Filmer model | <biochemistry, chemistry> A model to explain the allosteric form of cooperativity; in this model, in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits. Synonym: Adair-Koshland-Nemethy-Filmer model, induced fit model. (05 Mar 2000) |
| additive model | A model in which the combined effect of several factors is the sum of the effects that would be produced by each of the factors in the absence of the others. (05 Mar 2000) |
| age-structured model | <epidemiology> A mathematical model which take into consideration the division of the host population into different age classes. Such models can used to consider the consequences of such factors as age-dependent infection, morbidity or mortality rates or of age-specific vaccination schedules. (05 Dec 1998) |
| animal model | Study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable to those that occur in human populations. (05 Mar 2000) |
| Bingham model | A model representing the flow behaviour of a Bingham plastic, in the idealised case. (05 Mar 2000) |
| biomedical model | A conceptual model of illness that excludes psychological and social factors and includes only biological factors in an attempt to understand a person's medical illness or disorder. (05 Mar 2000) |
| biopsychosocial model | A conceptual model that assumes that psychological and social factors must also be included along with the biological in understanding a person's medical illness or disorder. (05 Mar 2000) |
| genetic model | A formalised conjecture about the behaviour of a heritable structure in which the component terms are intended to have literal interpretation as standard structures of empirical genetics. (05 Mar 2000) |
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