| CSF-1 | Macrophage Colony Stimulating Factor |
|---|---|
| GM-CSF | Granulocyte-Macrophage Colony Stimulating Factor |
| rGM-CSF | recombinant Granulocyte-Macrophage Colony Stimulating Factor |
| ACU | acquired cold urticaria; acute care unit; agar colony-forming unit; ambulatory care unit |
| BAC | bacterial adherent colony; bacterial antigen complex; blood alcohol concentration; British Associati... |
| lenticular process of incus | A knob at the tip of the long limb of the incus which articulates with the stapes. Synonym: processus lenticularis incudis, lenticular apophysis, lenticular bone, orbicular bone, orbicular process, orbiculare, os orbiculare, os sylvii. (05 Mar 2000) |
|---|---|
| lenticular progressive degeneration | <gastroenterology, neurology> An inherited (autosomal recessive) disorder where there is excessive quantities of copper in the tissues, particularly the liver and central nervous system. Wilson's disease causes the body to absorb and retain copper. The copper deposits in the liver, brain, kidneys and eyes. Complications include dementia and liver failure. Symptoms include jaundice, vomiting, tremors, weakness and slow stiff movements. Blood tests show serum ceruloplasmin is low. Medications are given to remove the excess copper from the body. Even with life-long treatment, disabling (and life-threatening) side effects are common. Inheritance: autosomal recessive. (27 Sep 1997) |
| lenticular syphilid | Eruption of flattened, dull reddish papules, 5 mm to 1 cm in diameter, occurring in secondary syphilis. Synonym: flat papular syphilid. (05 Mar 2000) |
| lenticular vesicle | In the embryo, the ectodermal invagination that forms opposite the optic cup; it is the primordium of the lens of the eye. Synonym: lenticular vesicle. (05 Mar 2000) |
| macrophage colony-stimulating factor | <growth factor> A glycoprotein growth factor that causes the committed cell line to proliferate and mature into macrophages. A cytokine synthesised by mesenchymal cells that stimulates pluripotent stem cells of bone marrow into differentiating towards the production of monocytes (mononuclear phagocytes). The compound stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. It is a disulfide-bonded glycoprotein dimer with a mw of 70 kD and binds to a single class of high affinity receptor which is identical to the product of the c-fms proto-oncogene. See: colony-stimulating factors. Chemical name: Colony-stimulating factor 1 Acronym: M-CSF (12 Dec 1998) |
| receptors, colony-stimulating factor | Cell surface receptors for colony-stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of haemopoietic cells. (12 Dec 1998) |
| receptors, granulocyte-colony-stimulating factor | Receptors that bind and internalise granulocyte-colony-stimulating factor. Their mw is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells. (12 Dec 1998) |
| receptors, granulocyte-macrophage colony-stimulating factor | Receptors that bind and internalise the granulocyte-macrophage stimulating factor. Their mw is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor. (12 Dec 1998) |
| receptors, macrophage colony-stimulating factor | Glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response. (12 Dec 1998) |
| Gheel colony | A colony in Gheel, Belgium, originating in the 13th century, for the informal communal care, in private homes, of severely mentally disordered persons. (05 Mar 2000) |
| granulocyte-colony-stimulating factor | <growth factor, haematology, oncology> A glycoprotein of 25 kD containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukaemic myeloid cell lines. A protein that stimulates the growth and maturation of granulocytes. It is used to promote the recovery of the white cells following chemotherapy. See: colony-stimulating factor. Acronym: G-CSF (12 Dec 1998) |
| granulocyte-macrophage colony-stimulating factor | <growth factor, haematology, oncology> An acidic glycoprotein of mw 23 kD with internal disulfide bonds. It is produced in response to a number of inflammatory mediators by mesenchymal cells present in the haemopoietic environment and at peripheral sites of inflammation. It stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from foetal liver progenitor cells. It also has some functional activities in mature granulocytes and macrophages. It is used to promote the recovery of the white blood cells following chemotherapy. Chemical name: Colony-stimulating factor 2 See: colony-stimulating factor. Acronym: GM-CSF (12 Dec 1998) |
| rough colony | A bacterial colony with a granular, flattened surface; this type of colony is usually associated with loss of virulence with respect to that of smooth colony's. (05 Mar 2000) |
| colony | <biology> A group of identical cells (clones) derived from a single parent cell. <cell culture> A clone of bacterial cells on a solid medium that is visible to the naked eye. (09 Oct 1997) |
| colony counter | A device which counts the number of colonies on an agar plate (a solid growth medium). (09 Oct 1997) |